Kalvaria I, Labadarios D, Shephard G S, Visser L, Marks I N
Gastrointestinal Clinic, Groote Schuur Hospital, Cape Town, South Africa.
Int J Pancreatol. 1986 Jul;1(2):119-28. doi: 10.1007/BF02788444.
In order to study the frequency of biochemical vitamin E deficiency in chronic alcohol-induced pancreatitis, we measured plasma vitamin E and total blood lipids in 44 patients with chronic pancreatitis and 83 control subjects (44 normal controls; 39 Crohn's disease controls). Mean plasma vitamin E and mean ratio vitamin E/total blood lipids, a more sensitive indicator of vitamin E status, were significantly lower in chronic pancreatitis when compared with either control group. A low vitamin E/total lipids ratio was found in 75% of patients with pancreatitis. Within the chronic pancreatitis group, mean plasma vitamin E and the ratio vitamin E to total lipids were significantly lower in those with steatorrhoea (23 patients--pancreatic steatorrhoea subgroup) than in those without (21 patients--pancreatic non-steatorrhoea subgroup). 91% of the pancreatic steatorrhoea subgroup had a low vitamin E/total lipids ratio. However, patients without pancreatic steatorrhoea also had significantly lower levels of plasma vitamin E and the ratio vitamin E/total lipids when compared to controls. We conclude that biochemical vitamin E deficiency is common in chronic alcohol-induced pancreatitis, particularly in patients with steatorrhoea, and that factors other than fat malabsorption may be responsible for vitamin E deficiency in pancreatic non-steatorrhoea.
为研究慢性酒精性胰腺炎中生化性维生素E缺乏的发生率，我们测定了44例慢性胰腺炎患者及83名对照者（44名正常对照；39名克罗恩病对照）的血浆维生素E和全血脂。与任一对照组相比，慢性胰腺炎患者的平均血浆维生素E及维生素E/全血脂比值（维生素E状态更敏感的指标）均显著降低。75%的胰腺炎患者维生素E/全血脂比值较低。在慢性胰腺炎组中，脂肪泻患者（23例——胰腺脂肪泻亚组）的平均血浆维生素E及维生素E与全血脂的比值显著低于无脂肪泻患者（21例——胰腺非脂肪泻亚组）。胰腺脂肪泻亚组中91%的患者维生素E/全血脂比值较低。然而，与对照组相比，无胰腺脂肪泻的患者血浆维生素E水平及维生素E/全血脂比值也显著降低。我们得出结论，生化性维生素E缺乏在慢性酒精性胰腺炎中常见，尤其是在脂肪泻患者中，且胰腺非脂肪泻患者中维生素E缺乏可能由脂肪吸收不良以外的因素所致。
