Thestrup-Pedersen K
Immunology. 1974 Dec;27(6):965-71.
Sixteen normal subjects were studied to see if a tuberculin skin test (Mantoux) would induce changes in their cell-mediated immune response (CMIR) as determined by a lymphocyte transformation test (LTT). In ten Mantoux-positive persons, a significant suppression of the responses to stimulation with both purified protein derivative (PPD) and phytohaemagglutinin (PHA) occurred. The suppression was seen within a week of the skin test. In three Mantoux-negative persons, an increase was seen in the response to stimulation with PPD, together with a significant suppression of the response to stimulation with PHA. Antibodies to PPD were found in low titres, but the titres did not change during the period of suppression of CMIR. The results show that a transient suppression of CMIR can be induced in normal individuals by the application of a small dose of antigen.
对16名正常受试者进行了研究,以观察结核菌素皮肤试验(曼托试验)是否会引起其细胞介导免疫反应(CMIR)的变化,该变化通过淋巴细胞转化试验(LTT)来测定。在10名曼托试验阳性者中,对纯化蛋白衍生物(PPD)和植物血凝素(PHA)刺激的反应出现了显著抑制。这种抑制在皮肤试验后的一周内可见。在3名曼托试验阴性者中,对PPD刺激的反应有所增加,同时对PHA刺激的反应出现了显著抑制。发现了低滴度的PPD抗体,但在CMIR抑制期间滴度没有变化。结果表明,对正常个体应用小剂量抗原可诱导CMIR的短暂抑制。