正常和白血病人类细胞的脱氧核糖核酸聚合酶在多脱氧核苷酸复制中的保真度
Fidelity of deoxyribonucleic acid polymerases from normal and leukaemic human cells in polydeoxynucleotide replication.
作者信息
Srivastava B I
出版信息
Biochem J. 1974 Aug;141(2):585-7. doi: 10.1042/bj1410585.
Abstract
Although the relative incorporation of incorrect nucleotide (dCTP or dGTP) into poly(dA-dT).poly(dA-dT) by partially purified 3-4S DNA polymerase from normal or leukaemic human cells was four to five times higher than that by the 6-7S DNA polymerase, no significant differences in the infidelity of these polymerases between normal and leukaemic cells were noted.
摘要
尽管从正常或白血病患者细胞中部分纯化得到的3-4S DNA聚合酶将错误核苷酸（dCTP或dGTP）掺入多聚（dA-dT）·多聚（dA-dT）中的相对掺入率比6-7S DNA聚合酶高4至5倍，但未发现这些聚合酶在正常细胞和白血病细胞之间的保真度存在显著差异。
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Biochem Biophys Res Commun. 1973 Apr 2;51(3):529-35. doi: 10.1016/0006-291x(73)91346-6.
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Deoxynucleotide-polymerizing enzymes in normal and malignant human cells.正常和恶性人类细胞中的脱氧核苷酸聚合酶。
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DNA polymerases I and II in regenerating rat liver and Morris hepatomas.再生大鼠肝脏和莫里斯肝癌中的DNA聚合酶I和II
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