一种与核内A 型颗粒相关的新型DNA聚合酶活性。
A novel DNA polymerase activity found in association with intracisternal A-type particles.
作者信息
Wilson S H, Kuff E L
出版信息
Proc Natl Acad Sci U S A. 1972 Jun;69(6):1531-6. doi: 10.1073/pnas.69.6.1531.
Abstract
A DNA polymerase activity that promotes the synthesis of poly(dT) has been found in association with intracisternal A-type particles isolated from several mouse tumors. The poly(dT) synthesis activity requires a DNA or RNA primer, is optimal at high salt concentration, prefers magnesium over manganese, and is stimulated by poly(rA). No significant incorporation of dAMP, dGMP, or dCMP was detected in the presence of several RNA and DNA template-primers. The enzyme activity differs in several of its properties from the poly(rA)-directed DNA polymerase activity associated with Rauscher murine leukemia virus.
摘要
在从几种小鼠肿瘤中分离出的核内A 型颗粒中，发现了一种促进多聚（dT）合成的DNA聚合酶活性。多聚（dT）合成活性需要DNA或RNA引物，在高盐浓度下最适宜，与锰相比更偏好镁，并且受到多聚（rA）的刺激。在几种RNA和DNA模板引物存在的情况下，未检测到dAMP、dGMP或dCMP的显著掺入。该酶活性在其几个特性上与劳斯氏鼠白血病病毒相关的多聚（rA）指导的DNA聚合酶活性不同。
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