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本文引用的文献

1
A molecular approach to the study of genic heterozygosity in natural populations. II. Amount of variation and degree of heterozygosity in natural populations of Drosophila pseudoobscura.一种研究自然种群基因杂合性的分子方法。II. 拟暗果蝇自然种群中的变异量和杂合度
Genetics. 1966 Aug;54(2):595-609. doi: 10.1093/genetics/54.2.595.
2
Evolutionary rate at the molecular level.分子水平的进化速率。
Nature. 1968 Feb 17;217(5129):624-6. doi: 10.1038/217624a0.
3
Average heterozygosity per locus in man: an estimate based on the incidence of enzyme polymorphisms.人类每个基因座的平均杂合性：基于酶多态性发生率的估计。
Ann Hum Genet. 1972 Jul;36(1):9-20. doi: 10.1111/j.1469-1809.1972.tb00578.x.

遗传背景与等位酶的适应性

Genetic background and the fitness of allozymes.

作者信息

Jones J S, Yamazaki T

出版信息

Genetics. 1974 Dec;78(4):1185-9. doi: 10.1093/genetics/78.4.1185.

DOI:10.1093/genetics/78.4.1185
PMID:4455555
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1213246/
Abstract

Experimental perturbations of gene frequency at the esterase-5 locus in Drosophila pseudoobscura were carried out in a series of population cages started with differing numbers of founder chromosomes. Cages founded with few chromosomes showed changes in gene frequency at the allozyme locus. Such changes were less marked in cages founded with a larger sample of chromosomes. These experiments show the importance of linkage disequilibrium in affecting allozyme frequencies, and emphasize the necessity of careful experimental design when studying fitness differences between allozymes in laboratory populations.

摘要

在一系列种群笼中对拟暗果蝇酯酶-5位点的基因频率进行了实验性扰动，这些种群笼起始于不同数量的奠基染色体。由少量染色体建立的笼子显示出等位酶位点基因频率的变化。在由更大样本染色体建立的笼子中，这种变化不太明显。这些实验表明连锁不平衡在影响等位酶频率方面的重要性，并强调在研究实验室种群中等位酶之间的适合度差异时进行仔细实验设计的必要性。