Jones J S, Yamazaki T
Genetics. 1974 Dec;78(4):1185-9. doi: 10.1093/genetics/78.4.1185.
Experimental perturbations of gene frequency at the esterase-5 locus in Drosophila pseudoobscura were carried out in a series of population cages started with differing numbers of founder chromosomes. Cages founded with few chromosomes showed changes in gene frequency at the allozyme locus. Such changes were less marked in cages founded with a larger sample of chromosomes. These experiments show the importance of linkage disequilibrium in affecting allozyme frequencies, and emphasize the necessity of careful experimental design when studying fitness differences between allozymes in laboratory populations.
在一系列种群笼中对拟暗果蝇酯酶-5位点的基因频率进行了实验性扰动,这些种群笼起始于不同数量的奠基染色体。由少量染色体建立的笼子显示出等位酶位点基因频率的变化。在由更大样本染色体建立的笼子中,这种变化不太明显。这些实验表明连锁不平衡在影响等位酶频率方面的重要性,并强调在研究实验室种群中等位酶之间的适合度差异时进行仔细实验设计的必要性。