甘油3-磷酸脱氢酶催化膦酸酯底物类似物的脱水反应。
Dehydration of a phosphonate substrate analogue by glycerol 3-phosphate dehydrogenase.
作者信息
Adams P R, Harrison R
出版信息
Biochem J. 1974 Sep;141(3):729-32. doi: 10.1042/bj1410729.
Abstract
S-(+)-3,4-Dihydroxybutylphosphonic acid, an isosteric analogue of sn-glycerol 3-phosphate, was synthesized stereospecifically and shown to be an effective substrate for rabbit muscle glycerol 3-phosphate dehydrogenase (sn-glycerol 3-phosphate-NAD(+) oxidoreductase, EC 1.1.1.8). Non-isosteric phosphonate analogues of sn-glycerol 3-phosphate showed neither substrate nor inhibitory activity with the enzyme.
摘要
S-(+)-3,4-二羟基丁基膦酸是sn-甘油-3-磷酸的等排类似物，已通过立体定向合成，并被证明是兔肌肉甘油-3-磷酸脱氢酶（sn-甘油-3-磷酸-NAD(+)氧化还原酶，EC 1.1.1.8）的有效底物。sn-甘油-3-磷酸的非等排膦酸类似物对该酶既无底物活性也无抑制活性。
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