植物血凝素诱导的淋巴细胞转化与系统性红斑狼疮疾病活动的关系。
Relationship of phytohaemagglutinin-induced lymphocyte transformation to disease activity in systemic lupus erythematosus.
作者信息
Hughes P, Holt S, Rowell N R, Dodd J K
出版信息
Ann Rheum Dis. 1976 Apr;35(2):97-105. doi: 10.1136/ard.35.2.97.
Phytohaemagglutinin-induced lymphocyte transformation was studied in 19 patients with systemic lupus erythematosus (SLE) in relation to disease activity, peripheral blood lymphocyte count, serum iron and folate levels, and corticosteroid treatment. Similar studies were performed on a group of 28 age- and sex-matched controls and on 10 patients with facial palsy who were examined before and after 7 days of high-dose corticosteroid treatment. The patients with SLE were found to have an impairment of lymphocyte transformation which was most marked in active stages of the disease and associated with a lymphopenia. This depressed transformation, which improved with the development of a remission, could not be attributed to the effects of corticosteroid treatment, inhibitory serum factors, iron deficiency, or any numerical reduction in blood lymphocytes, thus indicating along with evidence from other sources that SLE patients have a defect of cell-mediated immunity. The aetiological implications of these findings are discussed.
对19例系统性红斑狼疮（SLE）患者的植物血凝素诱导淋巴细胞转化进行了研究，该研究与疾病活动度、外周血淋巴细胞计数、血清铁和叶酸水平以及皮质类固醇治疗相关。对一组28名年龄和性别匹配的对照者以及10名面神经麻痹患者进行了类似研究，这些面神经麻痹患者在高剂量皮质类固醇治疗7天前后接受了检查。发现SLE患者存在淋巴细胞转化受损的情况，这在疾病的活动期最为明显，并与淋巴细胞减少相关。随着病情缓解，这种转化受抑情况有所改善，这不能归因于皮质类固醇治疗的影响、抑制性血清因子、缺铁或血液淋巴细胞数量的任何减少，因此，连同其他来源的证据表明，SLE患者存在细胞介导免疫缺陷。讨论了这些发现的病因学意义。
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