Kohli Y, Hattori S, Kodama T, Kawai K
Gastroenterol Jpn. 1979;14(1):14-8. doi: 10.1007/BF02774599.
The F-P border and strain phenomenon of the gastric mucosa were investigated by the application of methylene blue dye spraying method in endoscopy to 105 asymptomatic control volunteers and the following results were obtained; 1. The pyloric metaplasia is observed in the fundic gland area from the twenties in age and becomes increasing in its number and move widely spreading from the lesser curvature to the anterior and/or posterior wall of the corpus with advancing age. 2. The intestinal metaplasia arises from the thirties in age. 3. The intestinal metaplasia is observed either in the pyloric gland area of following the pyloric metaplasis in the fundic gland area. 4. Histologically, the strain phenomenon of the gastric mucosa is closely related to the intestinal metaplasia. Then, methylene blue dye spraying method is reevaluated to be useful for a precise endoscopic diagnosis of intestinal metaplasia.
通过在内镜检查中对105名无症状对照志愿者应用亚甲蓝染料喷洒法，研究了胃黏膜的F-P边界和应变现象，得出以下结果：1. 从20岁起在胃底腺区观察到幽门化生，随着年龄增长，其数量增加并从胃小弯广泛扩散至胃体前壁和/或后壁。2. 肠化生从30岁起出现。3. 在胃底腺区幽门化生后的幽门腺区观察到肠化生。4. 组织学上，胃黏膜的应变现象与肠化生密切相关。因此，重新评估亚甲蓝染料喷洒法对肠化生的精确内镜诊断有用。
