Kohli Y, Pfeiffer C J, Kutty K P, Barrowman J A, Heughan C, Kepkay D L
J Clin Gastroenterol. 1981;3 Suppl 1:29-33. doi: 10.1097/00004836-198100031-00006.
We carried out comparative studies on chronic atrophic gastritis with accompanying intestinal metaplasia using the methylene blue dye spraying, endoscopic technique on 167 Japanese and 77 Canadian outpatients free of gross stomach disease. In both population samples (Kyoto, Japan and St. John's, Newfoundland) with increasing subject age, the fundic-pyloric (F-P) border shifted cephalad indicating atrophy of the fundic mucosal glands. Japanese subjects, however, showed greater variation in location of the F-P border. The reduction in fundic gland area with aging was followed by intestinal metaplasia, the incidence and severity of which was greater in Japanese than in Canadian outpatients. From these data we conclude that a difference in the gastric mucosa in these two countries may be related to the pathogenesis of gastric cancer.
我们对167名日本门诊患者和77名加拿大门诊患者进行了比较研究，这些患者均无明显胃部疾病，采用亚甲蓝染料喷洒内镜技术对伴有肠化生的慢性萎缩性胃炎进行研究。在两个样本群体（日本京都和加拿大纽芬兰省圣约翰市）中，随着受试者年龄的增加，胃底-幽门（F-P）边界向上移位，提示胃底黏膜腺体萎缩。然而，日本受试者的F-P边界位置变化更大。随着年龄增长，胃底腺面积减少后出现肠化生，日本门诊患者中肠化生的发生率和严重程度高于加拿大门诊患者。根据这些数据，我们得出结论，这两个国家胃黏膜的差异可能与胃癌的发病机制有关。
