Kohli Y, Kato T, Suzuki K, Tada T, Fujiki N
Jpn J Med. 1987 May;26(2):158-61. doi: 10.2169/internalmedicine1962.26.158.
With methylene blue dye spraying endoscopy 392 Japanese outpatients with gastric diseases, and 253 Japanese and 84 Canadian outpatients free of gross findings in the stomach were investigated on chronic atrophic gastritis in special reference to intestinal metaplasia. Second, with the same technique 176 asymptomatic healthy residents in Kyoto, Japan, were also investigated, in which 50 residents were followed for two years and 32 subjects for four years. In each population subjects, with increasing age the fundic-pyloric (F-P) border shifted cephalad indicating atrophy of the fundic mucosa. Japanese subjects, however, showed greater variation in location of the F-P border, and also greater in symptomatic outpatients than in asymptomatic healthy subjects. The reduction in fundic gland area with aging was followed by intestinal metaplasia. In addition, our follow-up study indicates that atrophic gastritis was most likely to advance gradually with increasing age, even in asymptomatic residents.
采用亚甲蓝染料喷洒内镜检查了392例日本胃病门诊患者，还对253例日本门诊患者和84例加拿大门诊患者进行了检查，这些患者胃内均无明显病变，特别参照肠化生情况对慢性萎缩性胃炎进行了研究。其次，采用相同技术对日本京都的176名无症状健康居民进行了调查，其中50名居民随访了两年，32名受试者随访了四年。在各人群中，随着年龄增长，胃底-幽门（F-P）边界向上移位，提示胃底黏膜萎缩。然而，日本受试者的F-P边界位置变化更大，有症状的门诊患者比无症状的健康受试者变化也更大。随着年龄增长，胃底腺面积减少后会出现肠化生。此外，我们的随访研究表明，即使在无症状居民中，萎缩性胃炎也很可能随着年龄增长而逐渐进展。
