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携带二氢嘧啶核苷磷酸酶诱导性胰腺癌的金黄仓鼠中的核糖核酸酶水平

RNase levels in golden hamster with DHPN induced pancreatic cancer.

作者信息

Walton D, Nakazawa S, Kajikawa M, Naito Y, Ichikawa M, Kimoto E, Sano H, Suzuki Y, Asai T

出版信息

Gastroenterol Jpn. 1979;14(1):74-9. doi: 10.1007/BF02774607.

Abstract

Twenty Syrian golden hamsters recieved weekly injections of pancreatic cancer inducing DHPN. Their Poly (U) specific serum RNase levels were significantly elevated when compared to the control levels. Following salt fractionation, Poly (U) specific activity was present in both the 40% and 50% salt saturated fractions. Tissue assays showed that Poly (U) specific RNase was present in both pancreas and liver tissue extract, although the liver tissue RNase had a different pH maximum than that of the serum RNase.

摘要

二十只叙利亚金黄地鼠每周接受诱导胰腺癌的DHPN注射。与对照水平相比,它们的聚(U)特异性血清核糖核酸酶水平显著升高。盐分级分离后,聚(U)特异性活性存在于40%和50%盐饱和级分中。组织分析表明,胰腺和肝组织提取物中均存在聚(U)特异性核糖核酸酶,尽管肝组织核糖核酸酶的最适pH值与血清核糖核酸酶不同。

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