儿茶酚胺合成抑制对小鼠乙醇诱导的戒断症状的影响。
Effects of catecholamine synthesis inhibition on ethanol-induced withdrawal symptoms in mice.
作者信息
Blum K, Wallace J E
出版信息
Br J Pharmacol. 1974 May;51(1):109-11. doi: 10.1111/j.1476-5381.1974.tb09640.x.
Abstract
alpha-Methyl-p-tyrosine, a catecholamine synthesis inhibitor, was studied to determine its effects against ethanol-induced withdrawal symptoms in mice. Signifilcant (P < 0.001) potentiation of the withdrawal convulsion score induced by ethanol vapour exposure for three days was observed in mice. The synergistic effect was not due to alteration of ethanol metabolism. These results indicate that reductions in catecholamines (dopamine and noradrenaline) augment seizure activity induced by subchronic exposure to ethanol.
摘要
α-甲基对酪氨酸，一种儿茶酚胺合成抑制剂，被用于研究其对小鼠乙醇诱导戒断症状的影响。在小鼠中观察到，暴露于乙醇蒸汽三天所诱导的戒断惊厥评分有显著（P < 0.001）增强。这种协同效应并非由于乙醇代谢的改变。这些结果表明，儿茶酚胺（多巴胺和去甲肾上腺素）的减少会增强由亚慢性暴露于乙醇所诱导的癫痫发作活动。
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