Richerson H B, Rajtora D W, Penick G D, Dick F R, Yoo T J, Kammermeyer J K, Anuras J S
J Allergy Clin Immunol. 1979 Jul;64(1):67-77. doi: 10.1016/0091-6749(79)90085-x.
The present study was designed to test the hypotheses that late cutaneous and nasal responses to allergen in patients with ragweed hay fever were human correlates of cutaneous basophil hypersensitivity, and that late responses in the nose and skin reflect similar pathogenesis. Forty-seven patients with ragweed hay fever were studied during a ragweed season for peripheral basophilia and clinical patterns reflecting late responses. Provocative nasal challenge, skin testing, and biopsy were carried out subsequently in 21 of the same patients during the winter months. Conclusions were as follows: (1) no histologic features distinguish positive from negative late skin reactions at 24 hr in patients with immediate wheal-and-flare responses; (2) cutaneous basophil hypersensitivity, i.e., tissue basophilia, is not a distinguishing feature of late skin responses in ragweed pollenosis; (3) seasonal peripheral basophilia was not found; (4) late responses in the nose were difficult to document objectively and did not correlate with late skin reactions; and (5) lymphocyte responses to antigen failed to correlate with late responses in either the nose or the skin.
豚草花粉热患者对变应原的迟发性皮肤和鼻部反应是皮肤嗜碱性粒细胞超敏反应的人类相关表现，且鼻部和皮肤的迟发性反应反映了相似的发病机制。在豚草季节对47例豚草花粉热患者进行研究，观察外周嗜碱性粒细胞增多情况及反映迟发性反应的临床模式。随后在冬季对其中21例患者进行激发性鼻激发试验、皮肤试验和活检。结论如下：（1）在有即刻风团和潮红反应的患者中，24小时时阳性和阴性迟发性皮肤反应无组织学特征可区分；（2）皮肤嗜碱性粒细胞超敏反应，即组织嗜碱性粒细胞增多，不是豚草花粉症迟发性皮肤反应的特征性表现；（3）未发现季节性外周嗜碱性粒细胞增多；（4）鼻部迟发性反应难以客观记录，且与迟发性皮肤反应无关；（5）淋巴细胞对抗原的反应与鼻部或皮肤的迟发性反应均无相关性。
