Hiatt R A, Sotomayor Z R, Sanchez G, Zambrana M, Knight W B
J Infect Dis. 1979 Jun;139(6):659-66. doi: 10.1093/infdis/139.6.659.
Acute schistosomiasis mansoni was studied in 26 Puerto Rican patients whose clinical presentations differed widely in severity. Severity of illness was found to be positively correlated (r = 0.79) with the intensity of infection as measured by the concentration of eggs of Schistosoma mansoni in stool specimens. However, some patients had severe illness but relatively light infections. The disappearnace of symptoms and return toward normal of laboratory measures of disease activity were not associated with any diminution in the fecal egg count. Elevations of IgG, IgM, IgE, and of titers of anibody in serum indicated that the illness is associated with intense immune activity. The magnitude of the IgG and IgE responses was related to intensity of infection. The fact that incubation periods were shorter than the time needed for schistosomes to reach adulthood and lay eggs suggests that the syndrome can be initiated by parasite stages present before oviposition. No marked changes in complement (C3, C3p, C4, and CH50) and no signs of renal disease were noted in any of these patients.
对26名波多黎各曼氏血吸虫病急性期患者进行了研究，这些患者的临床表现严重程度差异很大。研究发现，疾病严重程度与感染强度呈正相关（r = 0.79），感染强度通过粪便标本中曼氏血吸虫卵的浓度来衡量。然而，一些患者病情严重但感染相对较轻。症状消失以及疾病活动实验室指标恢复正常与粪便虫卵计数的任何减少均无关联。血清中IgG、IgM、IgE升高以及抗体滴度升高表明该疾病与强烈的免疫活动有关。IgG和IgE反应的程度与感染强度有关。潜伏期短于血吸虫发育至成虫并产卵所需时间这一事实表明，该综合征可能由产卵前存在的寄生虫阶段引发。这些患者中无一出现补体（C3、C3p、C4和CH50）的明显变化，也无肾脏疾病迹象。
