Kojima S, Ito K, Murakami M, Nakamura T
Jpn Circ J. 1979 Jan;43(1):31-6. doi: 10.1253/jcj.43.31.
The present study was performed to investigate whether blood pressure of salt-loaded rats was influenced by the diet. Salt-loaded rats of Wistar strain were fed a high protein high fat diet or a high carbohydrate diet from the age of one month. The experiment was designed so that the intake of sodium chloride was equal in two groups. The body weight on the 14th week of the experiment was 394 +/- 15 g (Mean +/- SE) in the high protein high fat group, and 348 +/- 13 g in the high carbohydrate group. Blood pressure measured weekly by a tail plethysmographic method rose gradually and reached 176 +/- 5 mmHg (Mean +/- SE) on the 14th week in the high carbohydrate group. It was significantly higher than that (127 +/- 7 mmHg) of the high protein high fat group. The pressor responses to angiotensin and noradrenalin were also examined to investigate the mechanism through which salt hypertension was produced more easily by feeding a high carbohydrate diet. These responses to both drugs tended to be greater in the high carbohydrate group, but the differences between the two groups was not significant.
本研究旨在调查饮食是否会影响盐负荷大鼠的血压。从1月龄开始，给Wistar品系的盐负荷大鼠喂食高蛋白高脂肪饮食或高碳水化合物饮食。实验设计为两组的氯化钠摄入量相等。实验第14周时，高蛋白高脂肪组的体重为394±15克（均值±标准误），高碳水化合物组为348±13克。通过尾容积描记法每周测量的血压逐渐升高，高碳水化合物组在第14周时达到176±5毫米汞柱（均值±标准误）。这显著高于高蛋白高脂肪组（127±7毫米汞柱）。还检测了对血管紧张素和去甲肾上腺素的升压反应，以研究高碳水化合物饮食更容易引发盐性高血压的机制。高碳水化合物组对这两种药物的反应往往更大，但两组之间的差异不显著。
