Price J, Davis M, Ramu G
Lepr India. 1979 Jan;51(1):87-95.
In this study 0.1 ml of Dharmendra antigen was injected intradermally into the normal skin and lesions of 35 leprosy patients. The response was measured at 24 hrs., 48 hrs. and 21 days. It was found that the maximum response to Dharmendra antigen occurred at the end of 24 hrs. and started wanning by 48 hrs. In tuberculoid leprosy, there was significantly greater response in the lesion as compared with the nearby normal skin. It has been suggested that this could reflect an increased immunological activity at the site of the lesion. In the borderline tuberculoid cases with annular lesions, Dharmendra antigen was injected into the peripheral infiltrated area and into the apparently normal centre of the lesion, and a greater response was found at the centre. This might be the site of a previous lesion. The late reaction at the end of 21 days did not show much significant difference.
在本研究中，将0.1毫升达曼德拉抗原皮内注射到35例麻风患者的正常皮肤和皮损处。分别在24小时、48小时和21天时测量反应。结果发现，对达曼德拉抗原的最大反应出现在24小时末，到48小时时开始减弱。在结核样型麻风病中，皮损处的反应明显大于附近的正常皮肤。有人认为，这可能反映了皮损部位免疫活性的增强。在有环形皮损的界线结核样型病例中，将达曼德拉抗原注射到外周浸润区和皮损表面看似正常的中央部位，结果发现中央部位的反应更大。这可能是先前皮损的部位。21天末的迟发反应没有显示出太大的显著差异。
