再生大鼠肝脏中核事件的部分序列（基因调控 - 染色体RNA）
A partial sequence of nuclear events in regenerating rat liver (gene regulation-chromosomal RNA).
作者信息
Mayfield J E, Bonner J
出版信息
Proc Natl Acad Sci U S A. 1972 Jan;69(1):7-10. doi: 10.1073/pnas.69.1.7.
Abstract
When two lobes of the liver of the adult rat are removed, the cells of the remaining lobe are aroused to renewed cell division. We have studied the early events in such regeneration. The first observable response to such partial hepatectomy is the production in the liver nuclei of rapidly-labeled high-molecular-weight RNA of sequences not produced by normal liver. This is followed, with a lag of about 1 hr, by the appearance of increased (above normal) amounts of chromosomal RNA, again of sequences not produced by normal liver. With a lag of another hour, the template activity in support of RNA synthesis of the liver chromatin increases substantially. These events occur before initiation of DNA synthesis in the cells of the regenerating liver.
摘要
当成年大鼠的肝脏两个叶被切除时，剩余叶的细胞被激发重新进行细胞分裂。我们研究了这种再生过程中的早期事件。对这种部分肝切除术的第一个可观察到的反应是在肝细胞核中产生快速标记的高分子量RNA，其序列是正常肝脏所不产生的。大约1小时后，出现了（高于正常水平）数量增加的染色体RNA，同样其序列也是正常肝脏所不产生的。再过1小时，支持肝染色质RNA合成的模板活性大幅增加。这些事件发生在再生肝脏细胞中DNA合成开始之前。
相似文献
1
A partial sequence of nuclear events in regenerating rat liver (gene regulation-chromosomal RNA).再生大鼠肝脏中核事件的部分序列（基因调控 - 染色体RNA）
Proc Natl Acad Sci U S A. 1972 Jan;69(1):7-10. doi: 10.1073/pnas.69.1.7.
2
Template activities in normal, regenerating, and developing rat liver chromatin.正常、再生及发育中的大鼠肝脏染色质中的模板活性。
Proc Natl Acad Sci U S A. 1967 Nov;58(5):2055-62. doi: 10.1073/pnas.58.5.2055.
3
The appearance of new polyadenylated nuclear RNA sequences during rat-liver regeneration.大鼠肝脏再生过程中新的聚腺苷酸化核RNA序列的出现。
Nucleic Acids Res. 1981 Apr 24;9(8):2021-35. doi: 10.1093/nar/9.8.2021.
4
5
6
Changes in nuclear and polysomal polyadenylated RNA sequences during rat-liver regeneration.大鼠肝脏再生过程中细胞核和多核糖体多聚腺苷酸化RNA序列的变化
Nucleic Acids Res. 1979;6(6):2193-208. doi: 10.1093/nar/6.6.2193.
7
Characteristics of regenerating rat liver nuclear RNA.再生大鼠肝细胞核RNA的特征
Mol Biol. 1973 May-Jun;7(3):281-6.
8
Non-histone proteins and gene activation in regenerating rat liver.再生大鼠肝脏中的非组蛋白与基因激活
Exp Cell Res. 1973 Aug;80(2):291-6. doi: 10.1016/0014-4827(73)90299-1.
9
Studies on poly(A) sequences associated with regenerating liver RNA.与再生肝RNA相关的聚腺苷酸（poly(A)）序列研究。
Biochim Biophys Acta. 1974 Sep 27;366(1):23-34. doi: 10.1016/0005-2787(74)90314-1.
10
Role of endogenous regucalcin in nuclear regulation of regenerating rat liver: suppression of the enhanced ribonucleic acid synthesis activity.内源性调钙素在大鼠再生肝细胞核调控中的作用：对增强的核糖核酸合成活性的抑制
J Cell Biochem. 2002;87(4):450-7. doi: 10.1002/jcb.10325.
引用本文的文献
1
The problem of automation in animal development: confrontation of the concept of cell sociology with biochemical data.动物发育中的自动化问题：细胞社会学概念与生化数据的对峙。
Acta Biotheor. 1981;30(3):143-69. doi: 10.1007/BF00047007.
2
A chromosomal phosphoprotein is preferentially released by mild micrococcal-nuclease digestion.一种染色体磷蛋白优先通过温和的微球菌核酸酶消化释放出来。
Biochem J. 1984 Jun 1;220(2):539-45. doi: 10.1042/bj2200539.
3
Thymidine kinase and deoxyribonucleic acid metabolism in growing and regenerating livers from rats on controlled feeding schedules.在按控制进食时间表喂养的大鼠生长和再生肝脏中胸苷激酶与脱氧核糖核酸代谢
Biochem J. 1973 Dec;136(4):955-66. doi: 10.1042/bj1360955.
4
The genetic control of protein synthesis: The haemoglobin model.蛋白质合成的遗传控制：血红蛋白模型。
J Clin Pathol Suppl (R Coll Pathol). 1974;8:1-11.
5
Changes in the number of binding sites for ribonucleic acid polymerase in chromatin of WI-38 fibroblasts stimulated to proliferate.受刺激增殖的WI-38成纤维细胞染色质中核糖核酸聚合酶结合位点数量的变化。
Biochem J. 1974 Jul;141(1):27-34. doi: 10.1042/bj1410027.
6
Increased RNA synthesis in nuclear monolayers of WI-38 cells stimulated to proliferate.在被刺激增殖的WI-38细胞核单层中RNA合成增加。
Proc Natl Acad Sci U S A. 1974 May;71(5):2038-42. doi: 10.1073/pnas.71.5.2038.
7
Some observations on liver cell proliferation in the isolated perfused rat liver.关于离体灌注大鼠肝脏中肝细胞增殖的一些观察
Br J Exp Pathol. 1974 Jun;55(3):251-59.
8
Immunoglobulin allotypic specificities in mixed leucocyte cultures.混合白细胞培养中的免疫球蛋白同种异型特异性
Immunology. 1973 Jun;24(6):1041-9.
9
Monoclonal antibodies to a phosphoprotein from chromatin of rat liver.针对大鼠肝脏染色质中一种磷蛋白的单克隆抗体。
Biochem J. 1985 Jan 15;225(2):357-63. doi: 10.1042/bj2250357.
10
Chromatin-associated RNA content of heterochromatin and euchromatin.异染色质和常染色质的染色质相关RNA含量。
Mol Cell Biochem. 1975 Oct 31;9(1):9-16. doi: 10.1007/BF01731728.
本文引用的文献
1
The Biology of Isolated Chromatin: Chromosomes, biologically active in the test tube, provide a powerful tool for the study of gene action.孤立染色质的生物学：在试管中具有生物活性的染色体为研究基因作用提供了一个有力的工具。
Science. 1968 Jan 5;159(3810):47-56. doi: 10.1126/science.159.3810.47.
2
Deoxyribo ucleic acid-directed synthesis of ribonucleic acid by an enzyme from Escherichia coli.大肠杆菌中一种酶催化的脱氧核糖核酸指导的核糖核酸合成。
Proc Natl Acad Sci U S A. 1962 Jan 15;48(1):81-94. doi: 10.1073/pnas.48.1.81.
3
Ribonucleic acid synthesis in regenerating and embryonic liver. I. The synthesis of new species of RNA during regeneration of mouse liver after partial hepatectomy.再生肝和胚胎肝中的核糖核酸合成。I. 部分肝切除术后小鼠肝脏再生过程中新型RNA的合成。
J Mol Biol. 1967 Feb 14;23(3):459-75. doi: 10.1016/s0022-2836(67)80118-9.
4
Template activity of DNA is restricted in chromatin.DNA的模板活性在染色质中受到限制。
J Mol Biol. 1966 Mar;16(1):242-4. doi: 10.1016/s0022-2836(66)80276-0.
5
Chromosomal ribonucleic acid of rat ascites cells.大鼠腹水细胞的染色体核糖核酸
Biochemistry. 1969 Apr;8(4):1524-34. doi: 10.1021/bi00832a031.
6
Gene regulation for higher cells: a theory.高等细胞的基因调控：一种理论
Science. 1969 Jul 25;165(3891):349-57. doi: 10.1126/science.165.3891.349.
7
8
Specificity of transcription of chromatin in vitro.体外染色质转录的特异性
J Mol Biol. 1970 Jun 28;50(3):641-53. doi: 10.1016/0022-2836(70)90090-2.
9
Effect of protein-bound RNA associated with chick embryo chromatin on template specificity of the chromatin.与鸡胚染色质相关的蛋白质结合RNA对染色质模板特异性的影响。
J Mol Biol. 1969 Jan;39(2):365-78. doi: 10.1016/0022-2836(69)90323-4.
10
Sequence-specific interaction of DNA and chromosomal protein.DNA与染色体蛋白的序列特异性相互作用。
J Mol Biol. 1969 Jan;39(2):351-64. doi: 10.1016/0022-2836(69)90322-2.
Zotero 插件