遗传背景如何掩盖果蝇中的单基因杂种优势（多态性 - 选择 - 同工酶 - 近亲繁殖 - 果蝇）
How genetic background masks single-gene heterosis in Drosophila (polymorphism-selection-isoenzymes-inbreeding-fly).
作者信息
Wills C, Nichols L
出版信息
Proc Natl Acad Sci U S A. 1972 Feb;69(2):323-5. doi: 10.1073/pnas.69.2.323.
Abstract
Conditional heterosis associated with two isoallelic forms of octanol dehydrogenase in Drosophila pseudoobscura has been detected in flies that have been (a) inbred for several generations to make the background genotype as homozygous as practicable, and (b) grown on a medium containing a small amount of octanol. The heterosis was first found in inbred males. The possibility that the effect in females was masked by X-linked polymorphic genes affecting the same fitness components as the locus for octanol dehydrogenase was shown to be correct when, on further inbreeding, heterosis was found in the females of one of the lines. The implications of this and other findings for the current understanding of the genetic structure of natural populations is discussed.
摘要
在果蝇中，与辛醇脱氢酶的两种等位基因形式相关的条件杂种优势已在以下果蝇中被检测到：（a）经过几代近亲繁殖以使背景基因型尽可能纯合；（b）在含有少量辛醇的培养基上生长。杂种优势最初在近交雄性中被发现。当进一步近亲繁殖时，在其中一个品系的雌性中也发现了杂种优势，这表明影响与辛醇脱氢酶基因座相同适合度成分的X连锁多态基因掩盖了雌性中的效应这一可能性是正确的。本文讨论了这一发现及其他发现对当前自然种群遗传结构理解的意义。
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