具有改变形式的RNA聚合酶II的哺乳动物细胞。
Mammalian cells with altered forms of RNA polymerase II.
作者信息
Chan V L, Whitmore G F, Siminovitch L
出版信息
Proc Natl Acad Sci U S A. 1972 Nov;69(11):3119-23. doi: 10.1073/pnas.69.11.3119.
Abstract
Mutants of Chinese hamster ovary cells that are resistant to alpha-amanitin can be isolated. At least some of these mutants contain an altered form of DNA-dependent RNA polymerase II, as indicated by its resistance to alpha-amanitin. These results indicate that mutation to alpha-amanitin resistance involves a change of a structural gene.
摘要
可以分离出对α-鹅膏蕈碱具有抗性的中国仓鼠卵巢细胞突变体。这些突变体中至少有一些含有DNA依赖性RNA聚合酶II的变体形式，这可由其对α-鹅膏蕈碱的抗性表明。这些结果表明，向α-鹅膏蕈碱抗性的突变涉及结构基因的改变。
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