Jones P A, Miller F M, Worwood M, Jacobs A
Br J Cancer. 1973 Mar;27(3):212-7. doi: 10.1038/bjc.1973.26.
The serum ferritin concentration is increased in both acute myeloblastic leukaemia and Hodgkin's disease. In acute leukaemia the mean concentration is about ten times the normal level and is associated with a high concentration of transferrin-bound iron. In Hodgkin's disease abnormal ferritinaemia is associated with a low concentration of transferrin-bound iron and appears to result from a block of reticuloendothelial iron release. Increased concentrations of circulating ferritin have also been observed in a few cases of chronic leukaemia and myelomatosis.
急性髓细胞白血病和霍奇金病患者的血清铁蛋白浓度均升高。在急性白血病中,平均浓度约为正常水平的10倍,且与转铁蛋白结合铁的高浓度相关。在霍奇金病中,异常铁蛋白血症与转铁蛋白结合铁的低浓度相关,似乎是由于网状内皮系统铁释放受阻所致。在少数慢性白血病和骨髓瘤病例中也观察到循环铁蛋白浓度升高。