血液系统恶性肿瘤患者的铁代谢与真菌感染
Iron metabolism and fungal infections in patients with haematological malignancies.
作者信息
Iglesias-Osma C, Gonzalez-Villaron L, San Miguel J F, Caballero M D, Vazquez L, de Castro S
机构信息
Departamento de Medicina, Hospital Universitario, Universidad de Salamanca, Paseo San Vicente, Spain.
出版信息
J Clin Pathol. 1995 Mar;48(3):223-5. doi: 10.1136/jcp.48.3.223.
AIM
To determine whether iron metabolism influences the incidence of systemic fungal infection in patients with haematological malignancies.
METHODS
The study population comprised 74 patients who had undergone myeloablative chemotherapy. Systemic fungal infections were classified as confirmed (histological confirmation or characteristic septate hyphae) or possible (antibiotic resistant fever which resolved following administration of intravenous amphotericin B, together with either typical radiographic lesions or massive oropharyngeal candidiasis). Parameters of iron metabolism included serum iron concentrations, total iron binding capacity, serum transferrin, and ferritin concentrations and transferrin saturation values.
RESULTS
Patients who developed a fungal infection had substantially increased transferrin saturation values and ferritin concentrations at diagnosis together with low serum transferrin and high serum iron concentrations. This profile was present in patients with a fungal infection regardless of the underlying haematological disorder.
CONCLUSION
Increased transferrin saturation values and high ferritin concentrations may be additional risk factors for the development of systemic fungal infection in patients with haematological malignancies.
目的
确定铁代谢是否影响血液系统恶性肿瘤患者发生系统性真菌感染的几率。
方法
研究人群包括74例接受清髓性化疗的患者。系统性真菌感染分为确诊（组织学确诊或有特征性分隔菌丝）或疑似（静脉注射两性霉素B后消退的抗生素耐药性发热，伴有典型的影像学病变或大量口咽念珠菌病）。铁代谢参数包括血清铁浓度、总铁结合力、血清转铁蛋白、铁蛋白浓度和转铁蛋白饱和度值。
结果
发生真菌感染的患者在诊断时转铁蛋白饱和度值和铁蛋白浓度显著升高，同时血清转铁蛋白水平较低，血清铁浓度较高。无论潜在的血液系统疾病如何，真菌感染患者均呈现此特征。
结论
转铁蛋白饱和度值升高和铁蛋白浓度升高可能是血液系统恶性肿瘤患者发生系统性真菌感染的额外危险因素。
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