Morita R, Yoshii M, Nakajima K, Kohsaka T, Miki M, Torizuka K
Eur J Nucl Med. 1981;6(7):331-6. doi: 10.1007/BF00262528.
Serum ferritin levels were measured in 72 normal subjects and in 214 cases with various diseases by an immunoradiometric assay. In normal subjects, the serum ferritin levels were 27-230 mg/ml. Elevated serum ferritins were observed in most cases with iron excess and acute hepatitis. Markedly elevated levels were found in the majority of cases with acute leukemia, malignant lymphoma, hepatoma, and pancreatic cancer. High ferritin levels were also found in other malignant diseases. However, the range overlapped broadly with that of nonmalignant diseases. The serum ferritin correlated significantly with serum iron in normals and in those with iron deficiency anemia. In most nonmalignant cases, the serum ferritin and iron levels distributed on a regression line obtained from levels in normals and those with iron deficiency anemia. However, 92% of the malignant cases showed a serum ferritin to iron ratio higher than that of normal subjects. The estimation of the serum ferritin to iron ratio is a useful means for screening patients or in the differential diagnosis of a suspected malignant lesion.
采用免疫放射分析法对72名正常受试者和214例患有各种疾病的患者进行血清铁蛋白水平检测。正常受试者的血清铁蛋白水平为27 - 230毫克/毫升。大多数铁过量和急性肝炎病例的血清铁蛋白水平升高。大多数急性白血病、恶性淋巴瘤、肝癌和胰腺癌病例的血清铁蛋白水平显著升高。在其他恶性疾病中也发现高铁蛋白水平。然而，其范围与非恶性疾病的范围广泛重叠。在正常人和缺铁性贫血患者中，血清铁蛋白与血清铁显著相关。在大多数非恶性病例中，血清铁蛋白和铁水平分布在从正常人和缺铁性贫血患者水平获得的回归线上。然而，92%的恶性病例血清铁蛋白与铁的比值高于正常受试者。血清铁蛋白与铁比值的测定是筛查患者或鉴别疑似恶性病变的有用方法。
