未经治疗的霍奇金淋巴瘤患者的血清铁蛋白浓度。
Serum ferritin concentration in untreated Hodgkin's disease.
作者信息
Jacobs A, Slater A, Whittaker J A, Canellos G, Wiernik P H
出版信息
Br J Cancer. 1976 Aug;34(2):162-6. doi: 10.1038/bjc.1976.138.
Abstract
Serum ferritin has been estimated in 125 untreated patients with Hodgkin's disease. Increasing concentrations are found at each advancing stage of the disease and high concentrations are found in patients with systemic symptoms. In all cases this is associated with a low serum Fe concentration and reduced transferrin saturation. There is no relationship between serum ferritin concentration and histological type of disease. The findings are compatible with a non-specific response of the reticuloendothelial system to malignancy, producing a secondary disorder of Fe metabolism.
摘要
对125例未经治疗的霍奇金病患者的血清铁蛋白进行了评估。在疾病的每个进展阶段都发现血清铁蛋白浓度升高，有全身症状的患者血清铁蛋白浓度更高。在所有病例中，这都与血清铁浓度低和转铁蛋白饱和度降低有关。血清铁蛋白浓度与疾病的组织学类型之间没有关系。这些发现与网状内皮系统对恶性肿瘤的非特异性反应相符，导致铁代谢的继发性紊乱。
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