Davidson E H, Britten R J
Science. 1979 Jun 8;204(4397):1052-9. doi: 10.1126/science.451548.
Large contrasts are observed between the messenger RNA populations of different tissues and of embryos at different stages of development. Nevertheless, coding sequences for genes not expressed in a cell appear to be present in its nuclear RNA. Though many nuclear RNA transcripts of single copy DNA sequences are held in common between tissues, an additional set, probably consisting of non-message sequences, is not shared. Nuclear RNA also contains transcripts of repetitive DNA sequences. Certain repeat families are represented at high levels in the nuclear RNA of particular tissues and much lower levels in others. It is surprising that both complements of most repeat sequences are present in nuclear RNA. These observations lead to model for regulation of gene expression in which the formation of repetitive RNA-RNA duplexes controls the production of messenger RNA.
在不同组织以及处于不同发育阶段的胚胎的信使RNA群体之间，观察到了巨大差异。然而，未在细胞中表达的基因的编码序列似乎存在于其核RNA中。尽管单拷贝DNA序列的许多核RNA转录本在不同组织间是共有的，但另外一组可能由非信使序列组成的转录本却并非共享。核RNA还包含重复DNA序列的转录本。某些重复序列家族在特定组织的核RNA中含量很高，而在其他组织中含量则低得多。令人惊讶的是，大多数重复序列的互补序列都存在于核RNA中。这些观察结果引出了一种基因表达调控模型，其中重复RNA-RNA双链体的形成控制着信使RNA的产生。
