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1
Role of the polyadenylate segment in the translation of globin messenger RNA in Xenopus oocytes.聚腺苷酸片段在非洲爪蟾卵母细胞中珠蛋白信使核糖核酸翻译中的作用。
Proc Natl Acad Sci U S A. 1974 Aug;71(8):3143-6. doi: 10.1073/pnas.71.8.3143.
2
Readenylation of polyadenylate-free globin messenger RNA restores its stability in vivo.无聚腺苷酸的珠蛋白信使核糖核酸的再腺苷酸化可在体内恢复其稳定性。
Eur J Biochem. 1975 Nov 15;59(2):589-92. doi: 10.1111/j.1432-1033.1975.tb02486.x.
3
Translational properties of rabbit globin mRNA after specific removal of poly(A) with ribonuclease H.用核糖核酸酶H特异性去除多聚腺苷酸后兔珠蛋白mRNA的翻译特性
Proc Natl Acad Sci U S A. 1974 Nov;71(11):4635-9. doi: 10.1073/pnas.71.11.4635.
4
The translation of mammalian globin mRNA injected into fertilized eggs of Xenopus laevis. II. The distribution of globin synthesis in different tissues.注射到非洲爪蟾受精卵中的哺乳动物珠蛋白信使核糖核酸的翻译。II. 珠蛋白合成在不同组织中的分布。
Dev Biol. 1974 Jul;39(1):134-40. doi: 10.1016/s0012-1606(74)80015-1.
5
Translation of mouse globin messenger ribonucleic acid from which the poly(adenylic acid) sequence has been removed.已去除聚腺苷酸序列的小鼠珠蛋白信使核糖核酸的翻译产物。
Biochemistry. 1974 Feb 12;13(4):703-7. doi: 10.1021/bi00701a011.
6
The translation of mammalian globin mRNA injected into fertilized eggs of Xenopus laevis I. Message stability in development.注射到非洲爪蟾受精卵中的哺乳动物珠蛋白信使核糖核酸的翻译 一、发育过程中信使的稳定性
Dev Biol. 1974 Jul;39(1):125-33. doi: 10.1016/s0012-1606(74)80014-x.
7
Absence of polyadenylate segment in globin messenger RNA accelerates its degradation in Xenopus oocytes.珠蛋白信使核糖核酸中聚腺苷酸片段的缺失加速了其在非洲爪蟾卵母细胞中的降解。
Proc Natl Acad Sci U S A. 1975 Aug;72(8):3065-7. doi: 10.1073/pnas.72.8.3065.
8
Message stability in injected frog oocytes: long life of mammalian alpha and beta globin messages.注射到蛙卵母细胞中的信息稳定性：哺乳动物α和β珠蛋白信息的长寿命
J Mol Biol. 1973 Nov 5;80(3):539-51. doi: 10.1016/0022-2836(73)90421-x.
9
Globin mRNA species containing poly(A) segments of different lengths. Their functional stability in Xenopus oocytes.含有不同长度聚腺苷酸（poly(A)）片段的珠蛋白信使核糖核酸（mRNA）种类。它们在非洲爪蟾卵母细胞中的功能稳定性。
Eur J Biochem. 1976 Apr 15;64(1):115-21. doi: 10.1111/j.1432-1033.1976.tb10279.x.
10
Translation and stability of human globin mRNA in Xenopus oocytes.人珠蛋白mRNA在非洲爪蟾卵母细胞中的翻译及稳定性
J Clin Invest. 1976 Dec;58(6):1419-27. doi: 10.1172/JCI108597.

引用本文的文献

1
Mathematical Modeling of mRNA Poly(A) Tail Shortening Process.mRNA 多聚（A）尾缩短过程的数学建模。
Methods Mol Biol. 2024;2723:303-317. doi: 10.1007/978-1-0716-3481-3_18.
2
Functional expression of human α9* nicotinic acetylcholine receptors in X. laevis oocytes is dependent on the α9 subunit 5' UTR.功能性表达人源α9*烟碱型乙酰胆碱受体依赖于α9 亚基 5'UTR 在非洲爪蟾卵母细胞中的表达。
PLoS One. 2013 May 22;8(5):e64655. doi: 10.1371/journal.pone.0064655. Print 2013.
3
Using fluorometry and ion-sensitive microelectrodes to study the functional expression of heterologously-expressed ion channels and transporters in Xenopus oocytes.利用荧光法和离子敏感微电极研究异源表达的离子通道和转运体在非洲爪蟾卵母细胞中的功能表达。
Methods. 2010 May;51(1):134-45. doi: 10.1016/j.ymeth.2009.12.012. Epub 2010 Jan 4.
4
The ribonucleases of bovine skeletal muscle.牛骨骼肌的核糖核酸酶
Biochem J. 1980 Aug 1;189(2):263-75. doi: 10.1042/bj1890263.
5
Fluctuation in polyadenylate size and content in exponential- and stationary-phase cells of Saccharomyces cerevisiae.酿酒酵母指数生长期和稳定期细胞中聚腺苷酸大小和含量的波动
J Bacteriol. 1980 Oct;144(1):74-81. doi: 10.1128/jb.144.1.74-81.1980.
6
Translational stability of native and deadenylylated rabbit globin mRNA injected into HeLa cells.注射到HeLa细胞中的天然和去腺苷酸化兔珠蛋白mRNA的翻译稳定性。
Proc Natl Acad Sci U S A. 1981 Feb;78(2):908-11. doi: 10.1073/pnas.78.2.908.
7
Sequence organization of animal nuclear DNA.动物核DNA的序列组织
Hum Genet. 1980;55(1):1-18. doi: 10.1007/BF00329120.
8
Post-transcriptional modification of the poly(A) length of galactose-1-phosphate uridyl transferase mRNA in Saccharomyces cerevisiae.酿酒酵母中1-磷酸半乳糖尿苷酰转移酶mRNA的聚腺苷酸长度的转录后修饰
Nucleic Acids Res. 1980 Sep 11;8(17):3841-9. doi: 10.1093/nar/8.17.3841.
9
Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs.功能性信使核糖核酸通过克隆的互补脱氧核糖核酸的SP6体外转录产生。
Nucleic Acids Res. 1984 Sep 25;12(18):7057-70. doi: 10.1093/nar/12.18.7057.
10
Characterization of polyadenylated RNA in a protein-producing bacterium, Bacillus brevis 47.产蛋白细菌短短芽孢杆菌47中聚腺苷酸化RNA的特性分析
J Bacteriol. 1982 Sep;151(3):1162-70. doi: 10.1128/jb.151.3.1162-1170.1982.

本文引用的文献

1
Mammalian cell-free protein synthesis directed by viral ribonucleic acid.由病毒核糖核酸指导的哺乳动物无细胞蛋白质合成。
Eur J Biochem. 1970 Dec;17(2):328-38. doi: 10.1111/j.1432-1033.1970.tb01170.x.
2
Isolation and partial characterization of reticulocyte factors M1 and M2.网织红细胞因子M1和M2的分离及部分特性分析
J Biol Chem. 1970 Nov 10;245(21):5553-9.
3
Translational capacity of living frog eggs and oocytes, as judged by messenger RNA injection.通过信使核糖核酸注射判断的活蛙卵和卵母细胞的翻译能力。
J Mol Biol. 1971 Oct 14;61(1):93-103. doi: 10.1016/0022-2836(71)90208-7.
4
Release of messenger RNA from rabbit reticulocyte polyribosomes at low concentration of divalent cations.
Biochim Biophys Acta. 1967;145(3):629-36. doi: 10.1016/0005-2787(67)90122-0.
5
Use of frog eggs and oocytes for the study of messenger RNA and its translation in living cells.利用蛙卵和卵母细胞研究信使核糖核酸及其在活细胞中的翻译。
Nature. 1971 Sep 17;233(5316):177-82. doi: 10.1038/233177a0.
6
Message stability in injected frog oocytes: long life of mammalian alpha and beta globin messages.注射到蛙卵母细胞中的信息稳定性：哺乳动物α和β珠蛋白信息的长寿命
J Mol Biol. 1973 Nov 5;80(3):539-51. doi: 10.1016/0022-2836(73)90421-x.
7
Biogenesis of mRNA: genetic regulation in mammalian cells.信使核糖核酸的生物合成：哺乳动物细胞中的基因调控
Science. 1973 Sep 28;181(4106):1215-21. doi: 10.1126/science.181.4106.1215.
8
Evidence that all messenger RNA molecules (except histone messenger RNA) contain Poly (A) sequences and that the Poly(A) has a nuclear function.所有信使核糖核酸分子（组蛋白信使核糖核酸除外）均含有聚腺苷酸序列以及聚腺苷酸具有核功能的证据。
J Mol Biol. 1972 Oct 28;71(1):21-30. doi: 10.1016/0022-2836(72)90397-x.
9
Characteristics of the polyadenylic acid segment associated with messenger ribonucleic acid in mouse sarcoma 180 ascites cells.与小鼠肉瘤180腹水细胞中信使核糖核酸相关的聚腺苷酸片段的特征
Biochemistry. 1972 Feb 29;11(5):792-8. doi: 10.1021/bi00755a018.
10
Polyadenylic acid segment in mRNA becomes shorter with age.信使核糖核酸中的聚腺苷酸片段会随着年龄增长而变短。
Nat New Biol. 1973 Feb 28;241(113):265-8. doi: 10.1038/newbio241265a0.

聚腺苷酸片段在非洲爪蟾卵母细胞中珠蛋白信使核糖核酸翻译中的作用。

Role of the polyadenylate segment in the translation of globin messenger RNA in Xenopus oocytes.

作者信息

Huez G, Marbaix G, Hubert E, Leclercq M, Nudel U, Soreq H, Salomon R, Lebleu B, Revel M, Littauer U Z

出版信息

Proc Natl Acad Sci U S A. 1974 Aug;71(8):3143-6. doi: 10.1073/pnas.71.8.3143.

DOI:10.1073/pnas.71.8.3143
PMID:4528715
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC388638/
Abstract

The translations of native messenger RNA for rabbit globin and that of poly(A)-free globin messenger RNA have been compared after injection into Xenopus oocytes. The initial rate of translation of poly(A)-free mRNA is close to that found with intact mRNA. However, at longer incubation periods, the rate of globin synthesis with poly(A)-free mRNA is considerably lower than with native mRNA. Similar differences in the template activity of the two mRNA preparations were found with a cell-free extract of Krebs II ascites tumor. It is concluded that the presence of the 3' poly(A)-rich sequence in mRNA is required to ensure high functional stability.

摘要

将兔珠蛋白的天然信使核糖核酸（mRNA）和无聚腺苷酸（poly(A)）的珠蛋白信使核糖核酸注射到非洲爪蟾卵母细胞后，对二者的翻译情况进行了比较。无聚腺苷酸mRNA的初始翻译速率与完整mRNA的翻译速率相近。然而，在较长的孵育期，无聚腺苷酸mRNA的珠蛋白合成速率明显低于天然mRNA。在克雷布斯II腹水瘤细胞的无细胞提取物中，也发现了这两种mRNA制剂在模板活性上的类似差异。由此得出结论，mRNA中3'富含聚腺苷酸序列的存在是确保高功能稳定性所必需的。