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胸腺来源的玫瑰花结不是“辅助”细胞。

Thymus-derived rosettes are not "helper" cells.

作者信息

Elliott B E, Haskill J S, Axelrad M A

出版信息

J Exp Med. 1973 Nov 1;138(5):1133-43. doi: 10.1084/jem.138.5.1133.

DOI:10.1084/jem.138.5.1133
PMID:4126768
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2139438/
Abstract

Rosettes against SRBC were made from normal spleen cells. Although T rosettes tend to dissociate, they could be stabilized with 0.05% sodium azide. A clear separation of nonrosettes, T rosettes, and B rosettes was obtained by subjecting the suspension of splenic rosettes to velocity sedimentation at unit gravity. Each fraction was injected with either normal bone marrow cells or normal thymus cells with antigen into 650-R-irradiated hosts. Direct plaque-forming cells (PFC) were assayed in the spleens 7 days later. Synergism with thymus cells occurred only in the B-rosette fraction; PFC precursors therefore sedimented as B rosettes. Synergism with bone marrow cells occurred only in the nonrosette small lymphocyte fraction; helper cells therefore did not bind detectable numbers of sheep red blood cells (SRBC). Thus T rosettes are not helper cells in the direct PFC response of bone marrow B cells to SRBC.

摘要

抗绵羊红细胞（SRBC）玫瑰花结是由正常脾细胞制成的。虽然T玫瑰花结往往会解离，但可以用0.05%叠氮化钠使其稳定。通过使脾玫瑰花结悬液在单位重力下进行速度沉降，可将非玫瑰花结、T玫瑰花结和B玫瑰花结清晰分离。将每个组分与正常骨髓细胞或带有抗原的正常胸腺细胞一起注射到经650伦琴（R）照射的宿主体内。7天后在脾脏中检测直接溶血空斑形成细胞（PFC）。与胸腺细胞的协同作用仅发生在B玫瑰花结组分中；因此PFC前体细胞以B玫瑰花结形式沉降。与骨髓细胞的协同作用仅发生在非玫瑰花结小淋巴细胞组分中；因此辅助细胞不结合可检测数量的绵羊红细胞（SRBC）。因此，在骨髓B细胞对SRBC的直接PFC反应中，T玫瑰花结不是辅助细胞。

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本文引用的文献

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Separation of cells by velocity sedimentation.通过速度沉降法分离细胞。
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Further improvements in the plaque technique for detecting single antibody-forming cells.用于检测单个抗体形成细胞的蚀斑技术的进一步改进。
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T and B rosette-forming cells.T 细胞和 B 细胞玫瑰花结形成细胞。
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Surface immunoglobulins on thymus and thymus-derived lymphoid cells.胸腺及胸腺衍生淋巴细胞上的表面免疫球蛋白
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Altered antigen binding by immunocompetent cells as a reflexion of immunological history.免疫活性细胞抗原结合的改变作为免疫历史的一种反映。
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6
Early affect of adult thymectomy.成年胸腺切除术后的早期影响。
Nat New Biol. 1971 May 26;231(21):110-1. doi: 10.1038/newbio231110a0.
7
Cell cooperation in antibody induction. The susceptibility of helper cells to specific lethal radioactive antigen.抗体诱导中的细胞合作。辅助细胞对特异性致死性放射性抗原的敏感性。
Eur J Immunol. 1971 Jun;1(3):151-7. doi: 10.1002/eji.1830010302.
8
Cells mediating specific in vitro cytotoxicity. II. Probable autonomy of thymus-processed lymphocytes (T cells) for the killing of allogeneic target cells.介导特异性体外细胞毒性的细胞。II. 经胸腺处理的淋巴细胞（T细胞）杀伤同种异体靶细胞可能具有自主性。
J Exp Med. 1972 Apr 1;135(4):890-906. doi: 10.1084/jem.135.4.890.
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Antigen binding cells in tolerance and immunity.耐受性和免疫中的抗原结合细胞。
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Specific fractionation of immunocompetent cells.免疫活性细胞的特异性分级分离
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