伴刀豆球蛋白A对小鼠脾细胞悬液对抗原反应的抑制和刺激作用。II. 分别存在刺激细胞和抑制细胞的证据。
Inhibitory and stimulatory effects of concanavalin A on the response of mouse spleen cell suspensions to antigen. II. Evidence for separate stimulatory and inhibitory cells.
作者信息
Dutton R W
出版信息
J Exp Med. 1973 Dec 1;138(6):1496-505. doi: 10.1084/jem.138.6.1496.
Abstract
The addition of concanavalin A to mouse spleen cell suspensions can either inhibit or stimulate the immune response to heterologous erythrocytes according to the experimental conditions. Evidence is presented which is incompatible with the hypothesis that these two effects are mediated by a single cell and which favors the hypothesis of separate inhibitor and stimulatory cells.
摘要
根据实验条件，向小鼠脾细胞悬液中添加伴刀豆球蛋白A可抑制或刺激对异种红细胞的免疫反应。所提供的证据与这两种效应由单个细胞介导的假说不一致，而支持存在单独的抑制细胞和刺激细胞的假说。
相似文献
1
Inhibitory and stimulatory effects of concanavalin A on the response of mouse spleen cell suspensions to antigen. II. Evidence for separate stimulatory and inhibitory cells.伴刀豆球蛋白A对小鼠脾细胞悬液对抗原反应的抑制和刺激作用。II. 分别存在刺激细胞和抑制细胞的证据。
J Exp Med. 1973 Dec 1;138(6):1496-505. doi: 10.1084/jem.138.6.1496.
2
Inhibitory and stimulatory effects of concanavalin A on the response of mouse spleen cell suspensions to antigen. I. Characterization of the inhibitory cell activity.伴刀豆球蛋白A对小鼠脾细胞悬液对抗原反应的抑制和刺激作用。I. 抑制性细胞活性的特性
J Exp Med. 1972 Dec 1;136(6):1445-60. doi: 10.1084/jem.136.6.1445.
3
Competition between concanavalin A-induced stimulatory and inhibitory effects in the in vitro immune response to antigen.伴刀豆球蛋白A诱导的刺激作用与抑制作用在体外抗原免疫应答中的竞争
J Exp Med. 1975 Feb 1;141(2):524-9. doi: 10.1084/jem.141.2.524.
4
Cell-mediated immune responses in vitro. I. Suppression of the generation of cytotoxic lymphocytes by concanavalin A and concanavalin A-activated spleen cells.体外细胞介导的免疫反应。I. 伴刀豆球蛋白A和伴刀豆球蛋白A激活的脾细胞对细胞毒性淋巴细胞生成的抑制作用。
J Exp Med. 1974 Aug 1;140(2):356-69. doi: 10.1084/jem.140.2.356.
5
6
Effects of concanavalin A on the in vitro responses of mouse spleen cells to T-dependent and T-independent antigens.伴刀豆球蛋白A对小鼠脾细胞体外对T细胞依赖性和T细胞非依赖性抗原反应的影响。
J Immunol. 1975 Jan;114(1 Pt 2):365-70.
7
Antigen recognition. 3. Effect of phytomitogens on antigen-receptor capping and the immune response in vitro.抗原识别。3. 植物有丝分裂原对抗原受体帽化及体外免疫反应的影响。
Eur J Immunol. 1973 May;3(5):306-9. doi: 10.1002/eji.1830030510.
8
Reconstitution of immunocompetence in B cells by addition of concanavalin A or concanavalin A-treated thymus cells.通过添加伴刀豆球蛋白A或经伴刀豆球蛋白A处理的胸腺细胞来重建B细胞中的免疫活性。
Clin Exp Immunol. 1973 Feb;13(2):213-23.
9
Modulation of the antibody response to sheep erythrocytes in murine spleen cell cultures by a T cell mitogen extracted from Bordetella pertussis.从百日咳博德特氏菌中提取的一种T细胞有丝分裂原对小鼠脾细胞培养物中针对绵羊红细胞的抗体反应的调节作用。
Microbiol Immunol. 1978;22(1):47-51. doi: 10.1111/j.1348-0421.1978.tb00347.x.
10
Restriction of the mobility of lymphocyte immunoglobulin receptors by concanavalin A.伴刀豆球蛋白A对淋巴细胞免疫球蛋白受体流动性的限制
Proc Natl Acad Sci U S A. 1972 Mar;69(3):608-12. doi: 10.1073/pnas.69.3.608.
引用本文的文献
1
In vitro Studies of the Antibody Response: Antibodies of Different Specificity are Made in Different Populations of Cells.抗体反应的体外研究：不同特异性的抗体由不同细胞群体产生。
Front Immunol. 2014 Oct 28;5:515. doi: 10.3389/fimmu.2014.00515. eCollection 2014.
2
Concanavalin A-induced chemiluminescence in rat thymus lymphocytes. Its origin and role in mitogenesis.伴刀豆球蛋白A诱导大鼠胸腺淋巴细胞的化学发光。其起源及在有丝分裂中的作用。
Biochem J. 1981 Sep 15;198(3):661-7. doi: 10.1042/bj1980661.
3
4
TNP-Ficoll response in Xenopus laevis: substitution and reconstitution in thymectomized animals.非洲爪蟾对TNP - 菲可的反应：胸腺切除动物中的替代与重建
Immunology. 1984 Jul;52(3):483-9.
5
6
Selective inhibition of functional lymphocyte subpopulations by ribavirin.利巴韦林对功能性淋巴细胞亚群的选择性抑制作用。
Antimicrob Agents Chemother. 1982 Jul;22(1):108-14. doi: 10.1128/AAC.22.1.108.
7
Quantitative studies on T cell diversity. III. Limiting dilution analysis of precursor cells for T helper cells reactive to xenogeneic erythrocytes.T细胞多样性的定量研究。III. 对异种红细胞反应性T辅助细胞前体细胞的有限稀释分析。
J Exp Med. 1982 Dec 1;156(6):1587-603. doi: 10.1084/jem.156.6.1587.
8
Expression of theta antigen on mouse thymocytes during the cell cycle.小鼠胸腺细胞在细胞周期中θ抗原的表达。
Histochem J. 1982 Mar;14(2):273-81. doi: 10.1007/BF01041220.
9
Immunological functions of human T-lymphoid cell line (MOLT). I. Release of immunosuppressive factors from the mixture of MOLT-4 cells and sheep red blood cells.人T淋巴细胞系（MOLT）的免疫功能。I. MOLT - 4细胞与绵羊红细胞混合物中免疫抑制因子的释放。
J Exp Med. 1974 Aug 1;140(2):538-48. doi: 10.1084/jem.140.2.538.
10
Regulatory mechanisms in cell-mediated immune responses. I. Regulation of mixed lymphocyte reactions by alloantigen-activated thymus-derived lymphocytes.细胞介导免疫反应中的调节机制。I. 同种异体抗原激活的胸腺衍生淋巴细胞对混合淋巴细胞反应的调节。
J Exp Med. 1974 Dec 1;140(6):1588-603. doi: 10.1084/jem.140.6.1588.
本文引用的文献
1
Biological expressions of lymphocyte activation : I. Effects of phytomitogens on antibody synthesis in vitro.淋巴细胞激活的生物学表现：I. 植物促效剂对体外抗体合成的影响。
J Exp Med. 1973 Jan 31;137(2):205-23. doi: 10.1084/jem.137.2.205.
2
Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
3
'Nude', a new hairless gene with pleiotropic effects in the mouse.“裸”，一种在小鼠中具有多效性作用的新无毛基因。
Genet Res. 1966 Dec;8(3):295-309. doi: 10.1017/s0016672300010168.
4
5
Potentiation of the T-lymphocyte response to mitogens. II. The cellular source of potentiating mediator(s).T淋巴细胞对丝裂原反应的增强作用。II. 增强介质的细胞来源。
J Exp Med. 1972 Jul 1;136(1):143-55. doi: 10.1084/jem.136.1.143.
6
Inhibitory and stimulatory effects of concanavalin A on the response of mouse spleen cell suspensions to antigen. I. Characterization of the inhibitory cell activity.伴刀豆球蛋白A对小鼠脾细胞悬液对抗原反应的抑制和刺激作用。I. 抑制性细胞活性的特性
J Exp Med. 1972 Dec 1;136(6):1445-60. doi: 10.1084/jem.136.6.1445.
7
Reconstitution of immunocompetence in B cells by addition of concanavalin A or concanavalin A-treated thymus cells.通过添加伴刀豆球蛋白A或经伴刀豆球蛋白A处理的胸腺细胞来重建B细胞中的免疫活性。
Clin Exp Immunol. 1973 Feb;13(2):213-23.
8
Biological expressions of lymphocyte activation. II. Generation of a population of thymus-derived suppressor lymphocytes.淋巴细胞激活的生物学表现。II. 胸腺来源抑制性淋巴细胞群体的产生。
J Exp Med. 1973 Mar 1;137(3):649-59. doi: 10.1084/jem.137.3.649.
9
Activation of B lymphocytes by locally concentrated concanavalin A.局部浓缩伴刀豆球蛋白A对B淋巴细胞的激活作用
Eur J Immunol. 1972 Jun;2(3):233-5. doi: 10.1002/eji.1830020307.
10
Replacement of T-cell function by a T-cell product.用一种T细胞产物替代T细胞功能。
Nat New Biol. 1972 May 3;237(70):15-7. doi: 10.1038/newbio237015a0.
Zotero 插件