Dutton R W
J Exp Med. 1973 Dec 1;138(6):1496-505. doi: 10.1084/jem.138.6.1496.
The addition of concanavalin A to mouse spleen cell suspensions can either inhibit or stimulate the immune response to heterologous erythrocytes according to the experimental conditions. Evidence is presented which is incompatible with the hypothesis that these two effects are mediated by a single cell and which favors the hypothesis of separate inhibitor and stimulatory cells.
根据实验条件,向小鼠脾细胞悬液中添加伴刀豆球蛋白A可抑制或刺激对异种红细胞的免疫反应。所提供的证据与这两种效应由单个细胞介导的假说不一致,而支持存在单独的抑制细胞和刺激细胞的假说。