Connor J, Fine J, Kusano K, McCrea J, Parnas I, Prosser C L
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3301-4. doi: 10.1073/pnas.70.12.3301.
Bacterial endotoxin at concentrations of 0.03 mug/ml enhanced the following responses, each of which reflects calcium influx: (1) contraction of spiral intestine retractor muscle of dogfish; (2) amplitude of postsynaptic potential of squid giant synapse as a function of presynaptic depolarization; (3) membrane responses of deep abdominal extensor muscle of crayfish, stimulated intracellularly; and (4) slow transient (calcium) current in trabeculae of frog atrium under voltage clamp. Corticosteroid antagonized the endotoxin effect on the smooth muscle, not on the frog atrial current. One mechanism of action of endotoxin may be to increase transmembrane calcium currents.
浓度为0.03微克/毫升的细菌内毒素增强了以下反应,每个反应都反映了钙内流:(1)鲨鱼螺旋肠牵缩肌的收缩;(2)鱿鱼巨大突触的突触后电位幅度与突触前去极化的关系;(3)小龙虾腹部深层伸肌在细胞内刺激下的膜反应;(4)电压钳制下蛙心房小梁中的缓慢瞬态(钙)电流。皮质类固醇拮抗内毒素对平滑肌的作用,但不影响蛙心房电流。内毒素的一种作用机制可能是增加跨膜钙电流。