Foulis A K, Murray W R, Galloway D, McCartney A C, Lang E, Veitch J, Whaley K
Gut. 1982 Aug;23(8):656-61. doi: 10.1136/gut.23.8.656.
Twenty-four patients who experienced 26 attacks of acute pancreatitis were studied. Endotoxaemia, as measured by the limulus lysate assay, was present in 13 of the attacks. Six out of seven patients with systemic complications of the disease had endotoxaemia. C3 catabolism was increased in all 26 attacks of pancreatitis, and a falling level of C3 during attacks of severe pancreatitis was associated with a fatal outcome. There was statistical evidence of more complement activation in serum samples taken when patients had positive limulus lysate tests than when endotoxin was not detected in their blood.
对24例经历了26次急性胰腺炎发作的患者进行了研究。通过鲎试剂检测法测定，26次发作中有13次存在内毒素血症。该疾病出现全身并发症的7例患者中有6例存在内毒素血症。在所有26次胰腺炎发作中，C3分解代谢均增加，且重症胰腺炎发作期间C3水平下降与致命结局相关。有统计学证据表明，患者鲎试剂检测呈阳性时采集的血清样本中补体激活程度高于血液中未检测到内毒素时。
