感染鼠麻风杆菌的CFW小鼠中的抗体介导免疫。鼠麻风病中的体液免疫反应。

Antibody-mediated immunity in CFW mice infected with Mycobacterium lepraemurium. Humoral immune response in murine leprosy.

作者信息

Rojas-Espinosa O, Casoluengo-Méndez M, Díaz G V

出版信息

Clin Exp Immunol. 1976 Dec;26(3):381-7.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1540956/

Abstract

A depression in antibody-mediated immunity (AMI) measured both in terms of circulating antibody and plaque-forming cells in the spleen was observed in CFW mice infected with M. lepraemurium when sheep red blood cells (SRBC) and human gammaglobulin (HGG) were used as antigens. The impairment in AMI was evident only after 75 days of infection thereafter the antibody response to SRBC antigen progressively decreased until the last day of experimentation (135 days). Within the first 60 days of infection no alteration in AMI was observed with the HGG antigen while the response to the SRBC antigen was significantly higher in the infected animals than in uninfected controls.

摘要

当使用绵羊红细胞（SRBC）和人丙种球蛋白（HGG）作为抗原时，在感染鼠麻风杆菌的CFW小鼠中观察到抗体介导免疫（AMI）方面的降低，这是通过循环抗体和脾脏中的空斑形成细胞来衡量的。AMI的损害仅在感染75天后才明显，此后对SRBC抗原的抗体反应逐渐下降，直到实验的最后一天（135天）。在感染的前60天内，用HGG抗原未观察到AMI的改变，而感染动物对SRBC抗原的反应明显高于未感染的对照。

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本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。

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Studies of immune mechanisms in leprosy. 3. The role of cellular and humoral factors in impairment of the in vitro immune response.麻风病免疫机制研究。3. 细胞和体液因素在体外免疫反应受损中的作用。

J Immunol. 1971 Apr;106(4):888-99.

9

Hypergammaglobulinemia, secondary macroglobulinemia and paraproteinemia in leprosy.麻风病中的高球蛋白血症、继发性巨球蛋白血症和副蛋白血症。

Int J Lepr Other Mycobact Dis. 1969 Jul-Sep;37(3):280-7.

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A study of antibody response in leprosy.一项关于麻风病抗体反应的研究。

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