感染鼠麻风杆菌的CFW小鼠中的抗体介导免疫。鼠麻风病中的体液免疫反应。
Antibody-mediated immunity in CFW mice infected with Mycobacterium lepraemurium. Humoral immune response in murine leprosy.
作者信息
Rojas-Espinosa O, Casoluengo-Méndez M, Díaz G V
出版信息
Clin Exp Immunol. 1976 Dec;26(3):381-7.
A depression in antibody-mediated immunity (AMI) measured both in terms of circulating antibody and plaque-forming cells in the spleen was observed in CFW mice infected with M. lepraemurium when sheep red blood cells (SRBC) and human gammaglobulin (HGG) were used as antigens. The impairment in AMI was evident only after 75 days of infection thereafter the antibody response to SRBC antigen progressively decreased until the last day of experimentation (135 days). Within the first 60 days of infection no alteration in AMI was observed with the HGG antigen while the response to the SRBC antigen was significantly higher in the infected animals than in uninfected controls.
当使用绵羊红细胞（SRBC）和人丙种球蛋白（HGG）作为抗原时，在感染鼠麻风杆菌的CFW小鼠中观察到抗体介导免疫（AMI）方面的降低，这是通过循环抗体和脾脏中的空斑形成细胞来衡量的。AMI的损害仅在感染75天后才明显，此后对SRBC抗原的抗体反应逐渐下降，直到实验的最后一天（135天）。在感染的前60天内，用HGG抗原未观察到AMI的改变，而感染动物对SRBC抗原的反应明显高于未感染的对照。
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