Calder E A, Penhale W J, Barnes E W, Irvine W J
Br Med J. 1974 Apr 6;2(5909):30-1. doi: 10.1136/bmj.2.5909.30.
Anti-complementary activity was detected in the sera of 23 (59%) out of 39 patients with Hashimoto thyroiditis; in 10 (29%) out of 34 patients with primary hypothyroidism; in six (17%) out of 36 patients with thyrotoxicosis; and in only six (8%) out of 78 control subjects. Fractionation of Hashimoto sera by Sephadex G-200 chromatography showed that the anti-complementary activity was founding fractions of larger molecular size than monomeric IgG, being localized predominantly in the ascending limb of the second elution peak, suggesting that it was in the form of small immune complexes.
在39例桥本甲状腺炎患者中，23例（59%）的血清检测到抗补体活性；34例原发性甲状腺功能减退患者中，10例（29%）检测到抗补体活性；36例甲状腺毒症患者中，6例（17%）检测到抗补体活性；而78例对照受试者中只有6例（8%）检测到抗补体活性。用葡聚糖凝胶G - 200层析法对桥本甲状腺炎患者的血清进行分级分离，结果显示抗补体活性存在于分子大小比单体IgG更大的级分中，主要位于第二个洗脱峰的上升支，提示其为小免疫复合物的形式。
