通过喷射注射给予单价丙酮灭活伤寒疫苗和热灭活伤寒、副伤寒甲、乙三联疫苗后的反应及血清学反应。

Reactions and serologic responses to monovalent acetone-inactivated typhoid vaccine and heat-killed TAB when given by jet injection.

作者信息

Edwards E A, Johnson D P, Pierce W E, Peckinpaugh R O

出版信息

Bull World Health Organ. 1974;51(5):501-5.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2366309/

Abstract

Monovalent acetone-inactivated typhoid vaccine and heat-killed TAB caused local reactions in 82-88% of volunteers vaccinated by jet injection, whereas they caused local reactions in only 24% of volunteers injected by means of a conventional syringe. Both vaccines induced a high seroconversion rate to typhoid H antigen, but neither proved significantly immunogenic to antigens O and Vi. There was no increase in the occurrence of local reactions when a second jet injection was given 5 weeks after the first.

摘要

单价丙酮灭活伤寒疫苗和热灭活伤寒、副伤寒甲、乙三联疫苗在通过喷射注射接种的志愿者中，有82% - 88%出现局部反应，而通过传统注射器注射的志愿者中只有24%出现局部反应。两种疫苗都诱导了对伤寒H抗原的高血清转化率，但对O抗原和Vi抗原均未显示出显著的免疫原性。在第一次喷射注射5周后进行第二次喷射注射时，局部反应的发生率没有增加。

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Studies on infection and immunity in experimental typhoid fever. IV. Role of H antigen in protection.实验性伤寒热感染与免疫研究。IV. H抗原在保护中的作用。

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