中度严重上消化道出血对人体的代谢影响。
The metabolic effects of moderately severe upper gastrointestinal haemorrhage in man.
作者信息
Foster K J, Alberti K G, Binder C, Holdstock G, Karran S J, Smith C L, Talbot S, Turnell D C
出版信息
Postgrad Med J. 1982 Jan;58(675):25-9. doi: 10.1136/pgmj.58.675.25.
The metabolic effects of moderately severe gastrointestinal haemorrhage were investigated in man. Before resuscitation, patients had raised circulating concentrations of glucose, lactate, alanine, glycerol and cortisol. After urgent operation for haemorrhage, metabolite concentrations were similar to those of control patients having elective abdominal surgery, but insulin concentrations were higher and cortisol lower in haemorrhage patients. There were no significant differences in nitrogen excretion between haemorrhage patients and their controls, but urinary 3-methyl-histidine excretion by haemorrhage patients was lower indicating decreased muscle protein breakdown. Decreased amino acid release from muscle might account for previously reported imparied wound healing after haemorrhage.
对中度严重胃肠道出血的代谢影响在人体中进行了研究。在复苏前，患者的循环中葡萄糖、乳酸、丙氨酸、甘油和皮质醇浓度升高。在因出血进行紧急手术后，代谢物浓度与接受择期腹部手术的对照患者相似，但出血患者的胰岛素浓度较高，皮质醇浓度较低。出血患者与其对照组之间的氮排泄没有显著差异，但出血患者的尿3-甲基组氨酸排泄较低，表明肌肉蛋白分解减少。肌肉中氨基酸释放减少可能解释了先前报道的出血后伤口愈合受损的情况。
Zotero 插件