噬菌体T3感染细胞中大肠杆菌RNA聚合酶的一种抑制蛋白（核心聚合酶-σ因子-宿主聚合酶-噬菌体聚合酶-起始）
An inhibitory protein of Escherichia coli RNA polymerase in bacteriophage T3-infected cells (core polymerase-sigma factor-host polymerase-phage polymerase-initiation).
作者信息
Mahadik S P, Dharmgrongartama B, Srinivasan P R
出版信息
Proc Natl Acad Sci U S A. 1972 Jan;69(1):162-6. doi: 10.1073/pnas.69.1.162.
Abstract
A partially purified protein isolated from bacteriophage T3-infected cells of Escherichia coli B markedly inhibits the activity of E. coli RNA polymerase, slightly inhibits the activity of purified T3 polymerase, and does not inhibit the activity of either core polymerase or the ribosome-bound T3 polymerase. The properties of this protein and its mechanism of action have been studied. It appears to antagonize the action of the sigma factor component of RNA polymerase.
摘要
从噬菌体T3感染的大肠杆菌B细胞中分离出的一种部分纯化的蛋白质，能显著抑制大肠杆菌RNA聚合酶的活性，轻微抑制纯化的T3聚合酶的活性，而不抑制核心聚合酶或核糖体结合的T3聚合酶的活性。已对该蛋白质的性质及其作用机制进行了研究。它似乎拮抗RNA聚合酶的σ因子成分的作用。
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An inhibitory protein of Escherichia coli RNA polymerase in bacteriophage T3-infected cells (core polymerase-sigma factor-host polymerase-phage polymerase-initiation).噬菌体T3感染细胞中大肠杆菌RNA聚合酶的一种抑制蛋白（核心聚合酶-σ因子-宿主聚合酶-噬菌体聚合酶-起始）
Proc Natl Acad Sci U S A. 1972 Jan;69(1):162-6. doi: 10.1073/pnas.69.1.162.
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本文引用的文献
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Control of translation by T4 phage: altered binding of disfavoured messengers.T4噬菌体对翻译的控制：不利信使RNA结合的改变
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The process of infection with coliphage T7. V. Shutoff of host RNA synthesis by an early phage function.大肠杆菌噬菌体T7的感染过程。五、宿主RNA合成被噬菌体早期功能阻断。
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Different template specificities of phage T3 and T7 RNA polymerases.噬菌体T3和T7 RNA聚合酶不同的模板特异性。
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