Tang S W, Helmeste D M, Stancer H C
Can J Physiol Pharmacol. 1979 Apr;57(4):435-7. doi: 10.1139/y79-067.
The effects of some antidepressants on brain total 3-methoxy-4-hydroxyphenylglycol (MHPG) were studied in the rat. Desipramine decreased and mianserine increased the brain total MHPG concentration while the other antidepressants had no effect. They were also the only antidepressants that attenuated the lowering action of clonidine on brain total MHPG, but possibly through different mechanisms. Two tertiary amine tricyclic antidepressants, amitriptyline and imipramine, appeared to enhance the lowering action of clonidine on brain total MHPG. The results suggest that antidepressants are heterogeneous in their action on brain noradrenergic mechanisms in the rat.
在大鼠中研究了某些抗抑郁药对脑内总3-甲氧基-4-羟基苯乙二醇（MHPG）的影响。地昔帕明降低了脑内总MHPG浓度，而米安色林则使其升高，其他抗抑郁药则无此作用。它们也是仅有的能减弱可乐定对脑内总MHPG降低作用的抗抑郁药，但可能通过不同机制。两种叔胺类三环抗抑郁药，阿米替林和丙咪嗪，似乎增强了可乐定对脑内总MHPG的降低作用。结果表明，抗抑郁药对大鼠脑内去甲肾上腺素能机制的作用具有异质性。
