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The effect of clonidine withdrawal on total 3-methoxy-4-hydroxyphenylglycol in the rat brain.

作者信息

Tang S W, Helmeste D M, Stancer H C

出版信息

Psychopharmacology (Berl). 1979 Mar 14;61(1):11-2. doi: 10.1007/BF00426802.

DOI:10.1007/BF00426802
PMID:108714
Abstract

The effect of clonidine withdrawal on the brain norepinephrine system was studied in the rat. Clonidine suppresses brain total 3-methoxy-4-hydroxyphenylglycol (MHPG) significantly and no tolerance to this effect was observed up to 21 days. Cessation of clonidine treatment resulted in an elevation in the level of brain total MHPG. The suitability of the clonidine withdrawal syndrome as a model of bipolar depression is discussed.

摘要

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本文引用的文献

1
3-Methoxy-4-hydroxy phenylglycol (MHPG) excretion in depressive states. A pilot study.抑郁状态下3-甲氧基-4-羟基苯乙二醇（MHPG）的排泄：一项初步研究。
Arch Gen Psychiatry. 1968 Aug;19(2):129-34. doi: 10.1001/archpsyc.1968.01740080001001.
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Catecholamine metabolism in affective disorders. 3. MHPG and other catecholamine metabolites in patients treated with lithium carbonate.
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Studies on catecholamines, renin and aldosterone following Catapresan (2-(2,6-dichlor-phenylamine)-2-imidazoline hydrochloride) in hypertensive patients.高血压患者服用可乐宁（2-（2,6-二氯苯胺）-2-咪唑啉盐酸盐）后儿茶酚胺、肾素和醛固酮的研究。
Psychopharmacology (Berl). 1983;79(2-3):203-8. doi: 10.1007/BF00427813.
4
Effect of prolonged clonidine treatment and its withdrawal on noradrenaline turnover in the cerebral cortex and medulla oblongata of the spontaneously hypertensive rat.长期可乐定治疗及其撤药对自发性高血压大鼠大脑皮层和延髓去甲肾上腺素周转的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1987 Jul;336(1):77-80. doi: 10.1007/BF00177754.
5
Clonidine--induced behavioural despair in mice: reversal by antidepressants.可乐定诱导的小鼠行为绝望：抗抑郁药的逆转作用。
Psychopharmacology (Berl). 1986;89(2):171-4. doi: 10.1007/BF00310623.
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The catecholamine hypothesis of affective disorders: a review of supporting evidence.情感障碍的儿茶酚胺假说：支持证据综述
Am J Psychiatry. 1965 Nov;122(5):509-22. doi: 10.1176/ajp.122.5.509.
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Hypertension and depression: interrelated problems in therapy.高血压与抑郁症：治疗中的相关问题
J R Coll Physicians Lond. 1971 Oct;6(1):14-24.
6
Daily variations of the urine content of 3-methoxy-4-hydroxyphenylglycol in two manic-depressive patients.两名躁郁症患者尿液中3-甲氧基-4-羟基苯乙二醇含量的每日变化情况。
Psychol Med. 1972 Feb;2(1):81-5. doi: 10.1017/s0033291700045657.
7
Blood pressure crisis following withdrawal of clonidine (Catapres, Catapresan), with special reference to arterial and urinary catecholamine levels, and suggestions for acute management.
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Science. 1973 Jan 19;179(4070):300-2. doi: 10.1126/science.179.4070.300.
9
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Clin Chim Acta. 1977 Dec 1;81(2):182-92. doi: 10.1016/0009-8981(77)90010-9.
10
Discontinuation of chronic clonidine treatment: evidence for facilitated brain noradrenergic neurotransmission.慢性可乐定治疗的停药：脑去甲肾上腺素能神经传递增强的证据。
Naunyn Schmiedebergs Arch Pharmacol. 1977 Aug;299(1):83-7. doi: 10.1007/BF00508642.