Pantelouris E M, Flisch P A
Immunology. 1972 Jan;22(1):159-64.
The time course of the primary haemolysin response of thymusless `nude' mice to sheep red blood cells differs from that of intact animals in one main respect. After the initial peak, which is reached 4–6 days from injection of the cells, haemolysin level falls to zero at about Day 10; and there is a concurrent decline of the counts of plaque-forming cells. The prolonged phase of slow decline of haemolysin level, reflecting the production of 7S antibodies and typical of the response of normal animals, is absent. It is concluded that production of 7S haemolysins is thymus-dependent, whilst that of 19S haemolysins is thymus-independent.
无胸腺“裸”鼠对绵羊红细胞的主要溶血素反应的时间进程在一个主要方面与正常动物不同。在注射细胞后4 - 6天达到初始峰值后，溶血素水平在第10天左右降至零；同时，噬斑形成细胞计数也下降。正常动物反应中典型的、反映7S抗体产生的溶血素水平缓慢下降的延长阶段不存在。结论是，7S溶血素的产生依赖胸腺，而19S溶血素的产生不依赖胸腺。
