Hunter P, Munro A J
Immunology. 1972 Jul;23(1):69-80.
We have investigated the cell populations required for the and immune response of mouse spleen cells to rabbit Fab′ and Fab′ and sheep red blood cells (SRBC). The production of IgM antibodies to SRBC both in and is dependent upon the presence of thymus-derived lymphocytes, although some response does occur in their absence. The IgG response can only be obtained , and is also dependent upon the presence of thymus-derived lymphocytes. By contrast, the and IgM response of mice to rabbit Fab′ and Fab′ is independent of the presence of thymus-derived lymphocytes, but the IgG response is thymus dependent. The response to both SRBC and rabbit Fab′ is low in cultures depleted of macrophages, but the rabbit Fab′ response appears less affected by macrophage depletion than the SRBC response.
我们已经研究了小鼠脾细胞对兔Fab′和Fab′以及绵羊红细胞（SRBC）的免疫应答所需的细胞群体。在对SRBC产生IgM抗体的过程中，和都依赖于胸腺来源的淋巴细胞的存在，尽管在没有这些细胞的情况下也会发生一些应答。IgG应答只能在存在时获得，并且也依赖于胸腺来源的淋巴细胞的存在。相比之下，小鼠对兔Fab′和Fab′的和IgM应答不依赖于胸腺来源的淋巴细胞的存在，但IgG应答是胸腺依赖性的。在缺乏巨噬细胞的培养物中，对SRBC和兔Fab′的应答都很低，但兔Fab′应答似乎比SRBC应答受巨噬细胞耗竭的影响更小。
