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小鼠对兔F(ab')₂和Fab'的反应。IgM反应的胸腺非依赖性及IgG反应的胸腺依赖性。

Response of mice to rabbit Fab' 2 and Fab'. Thymus independence of IgM response and thymus dependence of IgG response.

作者信息

Hunter P, Munro A J

出版信息

Immunology. 1972 Jul;23(1):69-80.

PMID:4558094
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1407771/
Abstract

We have investigated the cell populations required for the and immune response of mouse spleen cells to rabbit Fab′ and Fab′ and sheep red blood cells (SRBC). The production of IgM antibodies to SRBC both in and is dependent upon the presence of thymus-derived lymphocytes, although some response does occur in their absence. The IgG response can only be obtained , and is also dependent upon the presence of thymus-derived lymphocytes. By contrast, the and IgM response of mice to rabbit Fab′ and Fab′ is independent of the presence of thymus-derived lymphocytes, but the IgG response is thymus dependent. The response to both SRBC and rabbit Fab′ is low in cultures depleted of macrophages, but the rabbit Fab′ response appears less affected by macrophage depletion than the SRBC response.

摘要

我们已经研究了小鼠脾细胞对兔Fab′和Fab′以及绵羊红细胞（SRBC）的免疫应答所需的细胞群体。在对SRBC产生IgM抗体的过程中，和都依赖于胸腺来源的淋巴细胞的存在，尽管在没有这些细胞的情况下也会发生一些应答。IgG应答只能在存在时获得，并且也依赖于胸腺来源的淋巴细胞的存在。相比之下，小鼠对兔Fab′和Fab′的和IgM应答不依赖于胸腺来源的淋巴细胞的存在，但IgG应答是胸腺依赖性的。在缺乏巨噬细胞的培养物中，对SRBC和兔Fab′的应答都很低，但兔Fab′应答似乎比SRBC应答受巨噬细胞耗竭的影响更小。

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本文引用的文献

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Studies on mouse leukaemia. The role of the thymus in leukaemogenesis by cell-free leukaemic filtrates.小鼠白血病研究。胸腺在无细胞白血病滤液致白血病过程中的作用。
Br J Cancer. 1960 Mar;14(1):93-8. doi: 10.1038/bjc.1960.11.
2
THE RESTORATION OF IMMUNOLOGICAL FUNCTION BY THYMUS GRAFTING IN THYMECTOMIZED IRRADIATED MICE.胸腺移植对经胸腺切除及照射的小鼠免疫功能的恢复作用
Transplantation. 1965 Jan;3:28-38. doi: 10.1097/00007890-196501000-00004.
3
A COMPARISON OF IMMUNOGLOBULINS AND ANTIBODY PRODUCTION IN THE NORMAL AND THYMECTOMIZED MOUSE.正常小鼠与胸腺切除小鼠免疫球蛋白及抗体产生的比较
J Immunol. 1964 Dec;93:915-25.
4
STUDIES ON GLOBULIN AND ANTIBODY PRODUCTION IN MICE THYMECTOMIZED AT BIRTH.新生期切除胸腺的小鼠球蛋白和抗体生成的研究。
Immunology. 1964 Jul;7(4):419-39.
5
A requirement for two cell types for antibody formation in vitro.体外抗体形成需要两种细胞类型。
Science. 1967 Dec 22;158(3808):1573-5. doi: 10.1126/science.158.3808.1573.
6
Features of antibody formation in neonatally thymectomized mice.新生期切除胸腺小鼠的抗体形成特征。
Nature. 1967 Apr 15;214(5085):295-7. doi: 10.1038/214295a0.
7
Immunization of dissociated spleen cell cultures from normal mice.对来自正常小鼠的脾细胞解离培养物进行免疫接种。
J Exp Med. 1967 Sep 1;126(3):423-42. doi: 10.1084/jem.126.3.423.
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Chemical and serological studies with an iodine-containing synthetic immunological determinant 4-hydroxy-3-iodo-5-nitrophenylacetic acid (NIP) and related compounds.对含碘合成免疫决定簇4-羟基-3-碘-5-硝基苯乙酸（NIP）及相关化合物的化学和血清学研究。
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J Gen Virol. 1968 Mar;2(2):309-12. doi: 10.1099/0022-1317-2-2-309.

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