海藻酸钠对小鼠针对绵羊红细胞的免疫反应的影响。
The effects of ALG on the murine immune response to sheep erythrocytes.
作者信息
Anderson H R, Dresser D W, Iverson G M, Lance E M, Wortis H H, Zebra J
出版信息
Immunology. 1972 Feb;22(2):277-89.
Antilymphocyte globulin (ALG), and to a lesser extent normal rabbit globulin (NRG), when given to mice prior to immunization with sheep-RBC suppress both the γM and γG responses. Globulin injected after the antigen suppresses the γG response, augments the γG response and has little effect on the γM response. These effects are also observed in mice partially paralysed to rabbit γ globulin. In another system—the response to hapten—protein conjugates precursors of antibody producing cells were found to be more resistant to ALS treatment than were helper cells. It is concluded that the suppressive effects of ALG treatment are largely due to the direct action of ALG on helper cells (T-cells). The mechanism of the adjuvant-like effect is unclear.
抗淋巴细胞球蛋白（ALG），以及在较小程度上的正常兔球蛋白（NRG），在小鼠用绵羊红细胞免疫之前给予时，会抑制γM和γG反应。抗原注射后注射的球蛋白会抑制γG反应，增强γG反应，而对γM反应影响很小。在对兔γ球蛋白部分麻痹的小鼠中也观察到了这些效应。在另一个系统——对半抗原-蛋白质偶联物的反应中——发现抗体产生细胞的前体比辅助细胞对抗淋巴细胞血清（ALS）治疗更具抗性。得出的结论是，ALG治疗的抑制作用主要是由于ALG对辅助细胞（T细胞）的直接作用。佐剂样效应的机制尚不清楚。
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