Montoliu J, Botey A, Torras A, Darnell A, Revert L
Clin Nephrol. 1979 May;11(5):267-71.
A 30 year old man developed renovascular hypertension and extreme elevation of plasma renin activity. Daily proteinuria ranged from 13 to 31 g. There were no criteria for the diagnosis of malignant hypertension. A primary glomerulopathy was excluded by a basically normal renal biopsy from the unprotected kidney. On electron microscopy the epithelial cell foot processes were not fused, thus ruling out simultaneous lipoid nephrosis. The source of renin was removed by means of a left nephrectomy. Following the procedure the patient became normotensive, the renin values normalized and the proteinuria disappeared. The results suggest that renin can cause significant proteinuria in man.
一名30岁男性出现肾血管性高血压，血浆肾素活性极度升高。每日蛋白尿范围为13至31克。没有恶性高血压的诊断标准。未受保护肾脏的肾活检基本正常，排除了原发性肾小球病。电子显微镜检查显示上皮细胞足突未融合，从而排除了同时存在的脂性肾病。通过左肾切除术去除了肾素来源。术后患者血压恢复正常，肾素值恢复正常，蛋白尿消失。结果表明，肾素可导致人类出现显著蛋白尿。
