通过基因倒位实现附加型整合的稳定：一个通用假说。
The stabilization of episomal integration by genetic inversion: a general hypothesis.
作者信息
Adelberg E A, Bergquist P
出版信息
Proc Natl Acad Sci U S A. 1972 Aug;69(8):2061-5. doi: 10.1073/pnas.69.8.2061.
Abstract
In F' cells of Escherichia coli K12, recombination in the region of genetic duplication between chromosome and F-genote produces a rapid alteration between the integrated and detached states of the episome. Nevertheless, F' strains can give rise to Hfr cells in which the F-genote has undergone stable integration. We have found that one such Hfr has retained the genetic duplication as well as the recombination proficiency of the parental F' strain; to account for the failure of recombination to detach the episome in this Hfr, we have postulated the inversion of one of the duplicated regions. A general model is presented, showing that an inversion must prevent episome detachment by any combination of genetic crossovers.
摘要
在大肠杆菌K12的F'细胞中，染色体与F-基因型之间基因重复区域的重组会使附加体在整合状态和游离状态之间快速转变。然而，F'菌株能够产生Hfr细胞，其中F-基因型已发生稳定整合。我们发现，这样一个Hfr保留了亲本F'菌株的基因重复以及重组能力；为了解释在这个Hfr中重组未能使附加体游离的原因，我们推测其中一个重复区域发生了倒位。本文提出了一个通用模型，表明倒位必定会通过任何基因交换组合来阻止附加体游离。
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