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1
Regulation of synthesis of the aminoacyl-transfer ribonucleic acid synthetases for the branched-chain amino acids of Escherichia coli.大肠杆菌支链氨基酸氨酰基转移核糖核酸合成酶合成的调控
J Bacteriol. 1971 Oct;108(1):254-62. doi: 10.1128/jb.108.1.254-262.1971.
2
Derepression of synthesis of the aminoacyl-transfer ribonucleic acid synthetases for the branched-chain amino acids of Escherichia coli.大肠杆菌支链氨基酸的氨酰基转移核糖核酸合成酶合成的去阻遏作用。
J Bacteriol. 1974 Aug;119(2):554-9. doi: 10.1128/jb.119.2.554-559.1974.
3
Regulation of branched-chain aminoacyl-transfer ribonucleic acid synthetases in an ilvDAC deletion strain of Escherichia coli K-12.大肠杆菌K-12 ilvDAC缺失菌株中支链氨基酸酰基转移核糖核酸合成酶的调控
J Bacteriol. 1975 Mar;121(3):785-93. doi: 10.1128/jb.121.3.785-793.1975.
4
Role of histidine transfer ribonucleic acid in regulation of synthesis of histidyl-transfer ribonucleic acid synthetase of Salmonella typhimurium.组氨酸转移核糖核酸在鼠伤寒沙门氏菌组氨酰转移核糖核酸合成酶合成调控中的作用。
J Bacteriol. 1972 Feb;109(2):505-11. doi: 10.1128/jb.109.2.505-511.1972.
5
Regulation of synthesis of methionyl-, prolyl-, and threonyl-transfer ribonucleic acid synthetases of Escherichia coli.大肠杆菌甲硫氨酰 -、脯氨酰 - 和苏氨酰 - 转移核糖核酸合成酶合成的调控
J Bacteriol. 1972 Mar;109(3):1020-6. doi: 10.1128/jb.109.3.1020-1026.1972.
6
Regulation of synthesis of the branched-chain amino acids and cognate aminoacyl-transfer ribonucleic acid synthetases of Escherichia coli: a common regulatory element.大肠杆菌支链氨基酸及相关氨酰基转移核糖核酸合成酶合成的调控：一种共同调控元件。
J Bacteriol. 1974 Dec;120(3):1380-6. doi: 10.1128/jb.120.3.1380-1386.1974.
7
Evidence that the majority of leucine transfer ribonucleic acid is not involved in repression in Salmonella typhimurium.有证据表明，鼠伤寒沙门氏菌中大多数亮氨酸转移核糖核酸不参与阻遏作用。
J Bacteriol. 1971 Nov;108(2):951-3. doi: 10.1128/jb.108.2.951-953.1971.
8
Growth-linked instability of a mutant valyl-transfer ribonucleic acid synthetase in Escherichia coli.大肠杆菌中一种突变缬氨酰转移核糖核酸合成酶与生长相关的不稳定性
J Bacteriol. 1972 Jan;109(1):315-25. doi: 10.1128/jb.109.1.315-325.1972.
9
Isolation and partial characterization of temperature-sensitive Escherichia coli mutants with altered leucyl- and seryl-transfer ribonucleic acid synthetases.具有改变的亮氨酰和丝氨酰转移核糖核酸合成酶的温度敏感型大肠杆菌突变体的分离及部分特性研究
J Bacteriol. 1971 Nov;108(2):742-50. doi: 10.1128/jb.108.2.742-750.1971.
10
Effect of cyclopentaneglycine on metabolism in Salmonella typhimurium.环戊甘氨酸对鼠伤寒沙门氏菌代谢的影响。
J Bacteriol. 1972 Aug;111(2):510-5. doi: 10.1128/jb.111.2.510-515.1972.

引用本文的文献

1
Studies on the regulation of the branched chain amino acyl-tRNA synthetases of the fungusNeurospora crassa.粗糙脉孢菌真菌支链氨基酸酰基 - tRNA合成酶的调控研究。
Wilehm Roux Arch Dev Biol. 1980 Oct;189(3):171-180. doi: 10.1007/BF00868675.
2
Multiple forms of lysyl-transfer ribonucleic acid synthetase in Escherichia coli.
J Bacteriol. 1981 Apr;146(1):345-51. doi: 10.1128/jb.146.1.345-351.1981.
3
Synthesis of branced-chain aminoacyl-transfer ribonucleid acid synthetases in a Salmonella typhimurium mutant with an altered biosynthetic L-threonine deaminase.鼠伤寒沙门氏菌中一种生物合成型L-苏氨酸脱氨酶发生改变的突变体中支链氨酰转移核糖核酸合成酶的合成。
J Bacteriol. 1974 Nov;120(2):604-7. doi: 10.1128/jb.120.2.604-607.1974.
4
Regulation of synthesis of the branched-chain amino acids and cognate aminoacyl-transfer ribonucleic acid synthetases of Escherichia coli: a common regulatory element.大肠杆菌支链氨基酸及相关氨酰基转移核糖核酸合成酶合成的调控：一种共同调控元件。
J Bacteriol. 1974 Dec;120(3):1380-6. doi: 10.1128/jb.120.3.1380-1386.1974.
5
Derepression of synthesis of the aminoacyl-transfer ribonucleic acid synthetases for the branched-chain amino acids of Escherichia coli.大肠杆菌支链氨基酸的氨酰基转移核糖核酸合成酶合成的去阻遏作用。
J Bacteriol. 1974 Aug;119(2):554-9. doi: 10.1128/jb.119.2.554-559.1974.
6
Regulation of methionyl-transfer ribonucleic acid synthetase formation in Escherichia coli and Salmonella typhimurium.大肠杆菌和鼠伤寒沙门氏菌中甲硫氨酰 - 转移核糖核酸合成酶形成的调控。
J Bacteriol. 1973 Jun;114(3):1007-13. doi: 10.1128/jb.114.3.1007-1013.1973.
7
Relationship between methionyl transfer ribonucleic acid cellular content and synthesis of methionine enzymes in Saccharomyces cerevisiae.酿酒酵母中甲硫氨酰转运核糖核酸细胞含量与甲硫氨酸酶合成之间的关系。
J Bacteriol. 1973 Mar;113(3):1156-60. doi: 10.1128/jb.113.3.1156-1160.1973.
8
Isolation and characterization of a regulatory mutant of an aminoacyl-transfer ribonucleic acid synthetase in Escherichia coli K-12.大肠杆菌K-12中氨酰基转移核糖核酸合成酶调节突变体的分离与鉴定。
J Bacteriol. 1973 Mar;113(3):1096-103. doi: 10.1128/jb.113.3.1096-1103.1973.
9
Effect of alanine, leucine and fructose on lysyl-transfer ribonucleic acid ligase activity in a mutant of Escherichia coli K-12.丙氨酸、亮氨酸和果糖对大肠杆菌K-12突变体中赖氨酰转移核糖核酸连接酶活性的影响
J Bacteriol. 1973 Jan;113(1):167-77. doi: 10.1128/jb.113.1.167-177.1973.
10
Regulation of synthesis of methionyl-, prolyl-, and threonyl-transfer ribonucleic acid synthetases of Escherichia coli.大肠杆菌甲硫氨酰 -、脯氨酰 - 和苏氨酰 - 转移核糖核酸合成酶合成的调控
J Bacteriol. 1972 Mar;109(3):1020-6. doi: 10.1128/jb.109.3.1020-1026.1972.

本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Control of isoleucine, valine, and leucine biosynthesis. I. Multivalent repression.异亮氨酸、缬氨酸和亮氨酸生物合成的调控。I. 多价阻遏
Proc Natl Acad Sci U S A. 1962 Oct 15;48(10):1804-8. doi: 10.1073/pnas.48.10.1804.
3
Use of chloramphenicol to study control of RNA synthesis in bacteria.使用氯霉素研究细菌中RNA合成的调控。
Biochim Biophys Acta. 1961 Oct 14;53:96-110. doi: 10.1016/0006-3002(61)90797-1.
4
Synthesis and inactivation of aminoacyl-transfer RNA synthetases during growth of Escherichia coli.大肠杆菌生长过程中氨酰 - 转移RNA合成酶的合成与失活
J Mol Biol. 1969 Aug 14;43(3):529-50. doi: 10.1016/0022-2836(69)90357-x.
5
Roles of amino acid activating enzymes in cellular physiology.氨基酸活化酶在细胞生理学中的作用。
Bacteriol Rev. 1966 Dec;30(4):701-19. doi: 10.1128/br.30.4.701-719.1966.
6
Biochemical and genetic characterization of a mutant of Escherichia coli with a temperature-sensitive valyl ribonucleic acid synthetase.具有温度敏感性缬氨酰核糖核酸合成酶的大肠杆菌突变体的生化与遗传特性
J Bacteriol. 1966 Oct;92(4):1076-82. doi: 10.1128/jb.92.4.1076-1082.1966.
7
Mutants of Salmonella typhimurium with an altered leucyl-transfer ribonucleic acid synthetase.鼠伤寒沙门氏菌中亮氨酰转运核糖核酸合成酶发生改变的突变体。
J Bacteriol. 1971 Apr;106(1):213-20. doi: 10.1128/jb.106.1.213-220.1971.
8
Mapping of a structural gene for valyl-transfer ribonucleic acid synthetase in Escherichia coli by transduction.通过转导对大肠杆菌中缬氨酰转移核糖核酸合成酶的结构基因进行定位。
J Bacteriol. 1969 May;98(2):837-9. doi: 10.1128/jb.98.2.837-839.1969.
9
Modification of valyl tRNA synthetase by bacteriophage in Escherichia coli.噬菌体对大肠杆菌中缬氨酰tRNA合成酶的修饰。
J Mol Biol. 1968 Feb 14;31(3):463-75. doi: 10.1016/0022-2836(68)90421-x.

大肠杆菌支链氨基酸氨酰基转移核糖核酸合成酶合成的调控

Regulation of synthesis of the aminoacyl-transfer ribonucleic acid synthetases for the branched-chain amino acids of Escherichia coli.

作者信息

McGinnis E, Williams L S

出版信息

J Bacteriol. 1971 Oct;108(1):254-62. doi: 10.1128/jb.108.1.254-262.1971.

DOI:10.1128/jb.108.1.254-262.1971
PMID:4941558
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC247059/
Abstract

The regulation of synthesis of valyl-, leucyl-, and isoleucyl-transfer ribonucleic acid (tRNA) synthetases was examined in strains of Escherichia coli and Salmonella typhimurium. When valine and isoleucine were limiting growth, the rate of formation of valyl-tRNA synthetase was derepressed about sixfold; addition of these amino acids caused repression of synthesis of this enzyme. The rate of synthesis of the isoleucyl- and leucyl-tRNA synthetases was derepressed only during growth restriction by the cognate amino acid. Restoration of the respective amino acid to these derepressed cultures caused repression of synthesis of the aminoacyl-tRNA synthetase, despite the resumption of the wild-type growth rate.

摘要

在大肠杆菌和鼠伤寒沙门氏菌菌株中研究了缬氨酰 -、亮氨酰 - 和异亮氨酰 - 转移核糖核酸（tRNA）合成酶的合成调控。当缬氨酸和异亮氨酸限制生长时，缬氨酰 - tRNA合成酶的形成速率去阻遏约6倍；添加这些氨基酸会导致该酶合成的阻遏。异亮氨酰 - 和亮氨酰 - tRNA合成酶的合成速率仅在同源氨基酸限制生长期间去阻遏。将相应氨基酸恢复到这些去阻遏的培养物中会导致氨酰 - tRNA合成酶合成的阻遏，尽管恢复了野生型生长速率。