大肠杆菌支链氨基酸氨酰基转移核糖核酸合成酶合成的调控
Regulation of synthesis of the aminoacyl-transfer ribonucleic acid synthetases for the branched-chain amino acids of Escherichia coli.
作者信息
McGinnis E, Williams L S
出版信息
J Bacteriol. 1971 Oct;108(1):254-62. doi: 10.1128/jb.108.1.254-262.1971.
Abstract
The regulation of synthesis of valyl-, leucyl-, and isoleucyl-transfer ribonucleic acid (tRNA) synthetases was examined in strains of Escherichia coli and Salmonella typhimurium. When valine and isoleucine were limiting growth, the rate of formation of valyl-tRNA synthetase was derepressed about sixfold; addition of these amino acids caused repression of synthesis of this enzyme. The rate of synthesis of the isoleucyl- and leucyl-tRNA synthetases was derepressed only during growth restriction by the cognate amino acid. Restoration of the respective amino acid to these derepressed cultures caused repression of synthesis of the aminoacyl-tRNA synthetase, despite the resumption of the wild-type growth rate.
摘要
在大肠杆菌和鼠伤寒沙门氏菌菌株中研究了缬氨酰 -、亮氨酰 - 和异亮氨酰 - 转移核糖核酸（tRNA）合成酶的合成调控。当缬氨酸和异亮氨酸限制生长时，缬氨酰 - tRNA合成酶的形成速率去阻遏约6倍；添加这些氨基酸会导致该酶合成的阻遏。异亮氨酰 - 和亮氨酰 - tRNA合成酶的合成速率仅在同源氨基酸限制生长期间去阻遏。将相应氨基酸恢复到这些去阻遏的培养物中会导致氨酰 - tRNA合成酶合成的阻遏，尽管恢复了野生型生长速率。
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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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