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通过异源抗原激活胸腺来源细胞（T细胞），以替代特异性免疫T细胞来传递对绵羊红细胞的二次应答。

Thymus-derived cell (T cell) activation by heterologous antigens as a replacement of specific immune T cells in the transfer of the secondary response to sheep erythrocytes.

作者信息

Mond J J, Takahashi T, Thorbecke G J

出版信息

J Exp Med. 1972 Oct 1;136(4):715-21. doi: 10.1084/jem.136.4.715.

DOI:10.1084/jem.136.4.715
PMID:4626849
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2139276/
Abstract

Spleen cells from LAF(1) mice hyperimmune to sheep erythrocytes (SE) lost their ability to transfer a secondary response to irradiated recipients after incubation with anti-theta and rabbit complement in vitro. Small numbers of specific immune cells even when taken 3 days after a primary SE injection reconstituted the direct and indirect plaque-forming cell responses. Larger numbers of cells sensitized to B. abortus (or keyhole limpet hemocyanin), and given together with the corresponding antigen, also partially reconstituted the ability to respond to SE. This property was mediated by theta-bearing cells and was interpreted as due to a nonspecific humoral factor liberated by specifically activated T cells and acting on B cell proliferation or maturation.

摘要

来自对绵羊红细胞（SE）高度免疫的LAF(1)小鼠的脾细胞，在体外与抗θ血清和兔补体孵育后，失去了向受辐照受体传递二次反应的能力。即使在初次注射SE后3天获取的少量特异性免疫细胞，也能重建直接和间接的空斑形成细胞反应。大量对流产布鲁氏菌（或钥孔血蓝蛋白）致敏并与相应抗原一起给予的细胞，也能部分重建对SE的反应能力。这种特性由携带θ的细胞介导，被解释为是由于特异性活化的T细胞释放的一种非特异性体液因子作用于B细胞增殖或成熟所致。

相似文献

1
Thymus-derived cell (T cell) activation by heterologous antigens as a replacement of specific immune T cells in the transfer of the secondary response to sheep erythrocytes.通过异源抗原激活胸腺来源细胞（T细胞），以替代特异性免疫T细胞来传递对绵羊红细胞的二次应答。
J Exp Med. 1972 Oct 1;136(4):715-21. doi: 10.1084/jem.136.4.715.
2
Cell interactions in the immune response in vitro. V. Specific collaboration via complexes of antigen and thymus-derived cell immunoglobulin.体外免疫反应中的细胞相互作用。V. 通过抗原与胸腺来源细胞免疫球蛋白复合物的特异性协作。
J Exp Med. 1972 Oct 1;136(4):737-60. doi: 10.1084/jem.136.4.737.
3
Surface antigens of immunocompetent cells. 3. In vitro studies of the role of B and T cells in immunological memory.免疫活性细胞的表面抗原。3. B细胞和T细胞在免疫记忆中作用的体外研究。
J Exp Med. 1972 Oct 1;136(4):663-75. doi: 10.1084/jem.136.4.663.
4
Effect of recent antigen priming on adoptive immune responses. I. Specific unresponsiveness of cells from lymphoid organs of mice primed with heterologous erythrocytes.近期抗原致敏对过继免疫反应的影响。I. 用异种红细胞致敏的小鼠淋巴器官细胞的特异性无反应性。
J Exp Med. 1973 Jul 1;138(1):143-62. doi: 10.1084/jem.138.1.143.
5
The asynchronous development of immunological memory in helper (T) and precursor (B) cell lines.辅助性（T）细胞系和前体（B）细胞系中免疫记忆的异步发育。
Eur J Immunol. 1971 Dec;1(6):413-21. doi: 10.1002/eji.1830010602.
6
Studies on antigen-binding cells. II. Relationship to antigen-sensitive cells.抗原结合细胞的研究。II. 与抗原敏感细胞的关系。
Cell Immunol. 1970 Oct;1(4):386-403. doi: 10.1016/0008-8749(70)90016-x.
7
Frequency of antigen-sensitive cells to thymus-independent antigens.抗原敏感细胞对非胸腺依赖性抗原的反应频率。
Cell Immunol. 1971 Aug;2(4):309-16. doi: 10.1016/0008-8749(71)90065-7.
8
Inhibition by anti- chain sera of the cellular transfer of antibody and immunoglobulin synthesis in mice.抗链血清对小鼠体内抗体细胞转移及免疫球蛋白合成的抑制作用。
J Immunol. 1972 Jun;108(6):1712-7.
9
The importance of theta and Ig hearing cells in the immune response to various antigens.θ细胞和Ig听力细胞在对各种抗原的免疫反应中的重要性。
J Immunol. 1971 Dec;107(6):1520-6.
10
Immunological memory in mice. 3. Memory to heterologous erythrocytes in both T cell and B cell populations and requirement for T cells in expression of B cell memory. Evidence using immunoglobulin allotype and mouse alloantigen theta markers with congenic mice.小鼠中的免疫记忆。3. T细胞和B细胞群体对异种红细胞的记忆以及B细胞记忆表达中对T细胞的需求。使用免疫球蛋白同种异型和小鼠同种异体抗原θ标记物及同基因小鼠的证据。
J Exp Med. 1972 Feb 1;135(2):165-84. doi: 10.1084/jem.135.2.165.

引用本文的文献

1
Establishment of an inbred line of mice that express a synergistic immune defect precluding in vitro responses to type 1 and type 2 antigens, B cell mitogens, and a number of T cell-derived helper factors.建立一种近交系小鼠，该小鼠表现出协同免疫缺陷，无法对1型和2型抗原、B细胞有丝分裂原以及多种T细胞衍生的辅助因子产生体外反应。
J Exp Med. 1983 Nov 1;158(5):1401-14. doi: 10.1084/jem.158.5.1401.
2
Selective DNA synthesis by cells specifically localizing in response to xenogeneic erythrocytes.细胞通过对异种红细胞特异性定位进行选择性DNA合成。
J Exp Med. 1973 Sep 1;138(3):659-71. doi: 10.1084/jem.138.3.659.
3
T cell-dependent mediator in the immune response. II. Physical and biological properties.免疫反应中T细胞依赖性介质。II. 物理和生物学特性。
Immunology. 1974 Jul;27(1):53-64.
4
Regulation of immunoglobulin synthesis by dextran.右旋糖酐对免疫球蛋白合成的调节
J Exp Med. 1973 Jul 1;138(1):176-93. doi: 10.1084/jem.138.1.176.
5
Surface antigens of immunocompetent cells. 3. In vitro studies of the role of B and T cells in immunological memory.免疫活性细胞的表面抗原。3. B细胞和T细胞在免疫记忆中作用的体外研究。
J Exp Med. 1972 Oct 1;136(4):663-75. doi: 10.1084/jem.136.4.663.
6
Cross-reactivity of T-cell 'helper' function.T 细胞“辅助”功能的交叉反应性。
Clin Exp Immunol. 1974 Sep;18(1):55-61.
7
Further studies on the H-2 linked dependence of the adjuvant action of Brucella abortus.布鲁氏菌佐剂作用的H-2连锁依赖性的进一步研究。
Immunology. 1978 May;34(5):807-14.
8
Induction of an immune response through interaction of helper cells with an immune complex bound to the surface of B cells.通过辅助细胞与结合在B细胞表面的免疫复合物相互作用诱导免疫应答。
Proc Natl Acad Sci U S A. 1975 Nov;72(11):4555-8. doi: 10.1073/pnas.72.11.4555.

本文引用的文献

1
Antibody formation: stimulation by polyadenylic and polycytidylic acids.抗体形成：聚腺苷酸和聚胞苷酸的刺激作用
Science. 1967 Aug 18;157(3790):819-21. doi: 10.1126/science.157.3790.819.
2
The carrier effect in the secondary response to hapten-protein conjugates. II. Cellular cooperation.对半抗原-蛋白质偶联物二次应答中的载体效应。II. 细胞协作。
Eur J Immunol. 1971 Jan;1(1):18-27. doi: 10.1002/eji.1830010104.
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THE AKR THYMIC ANTIGEN AND ITS DISTRIBUTION IN LEUKEMIAS AND NERVOUS TISSUES.AKR胸腺抗原及其在白血病和神经组织中的分布。
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EVIDENCE FOR A HUMORAL THYMUS FACTOR RESPONSIBLE FOR THE MATURATION OF IMMUNOLOGICAL FACULTY.一种负责免疫功能成熟的体液胸腺因子的证据。
Nature. 1963 Aug 17;199:653-4. doi: 10.1038/199653a0.
5
Lymphocyte stimulation: transfer of cellular hypersensitivity to antigen in vitro.淋巴细胞刺激：体外细胞超敏反应向抗原的转移。
Science. 1969 Sep 5;165(3897):1014-6. doi: 10.1126/science.165.3897.1014.
6
Influence of thymosin on immunological competence of lymphoid cells from thymectomized mice.胸腺素对去胸腺小鼠淋巴细胞免疫活性的影响。
Nature. 1968 Sep 28;219(5161):1391-2. doi: 10.1038/2191391a0.
7
Induction of a hemolysin response in vitro. Interaction of cells of bone marrow origin and thymic origin.体外溶血素反应的诱导。骨髓来源细胞与胸腺来源细胞的相互作用。
J Exp Med. 1970 Dec 1;132(6):1267-78. doi: 10.1084/jem.132.6.1267.
8
Surface antigens of immunocompetent cells. I. Effect of theta and PC.1 alloantisera on the ability of spleen cells to transfer immune responses.免疫活性细胞的表面抗原。I. θ和PC.1同种异体抗血清对脾细胞传递免疫反应能力的影响。
J Exp Med. 1970 Dec 1;132(6):1181-90. doi: 10.1084/jem.132.6.1181.
9
Reconstitution of a thymus cell-deprived immune system by syngeneic and allogeneic thymocytes in vitro.通过同基因和异基因胸腺细胞在体外重建胸腺细胞缺失的免疫系统。
Eur J Immunol. 1971 Aug;1(4):304-6. doi: 10.1002/eji.1830010419.
10
Initiation of antibody production to sheep erythrocytes in vitro: replacement of the requirement for T-cells with a cell-free factor isolated from cultures of lymphoid cells.体外针对绵羊红细胞的抗体产生起始：用从淋巴细胞培养物中分离出的无细胞因子替代对T细胞的需求。
J Immunol. 1972 Feb;108(2):547-51.