通过异源抗原激活胸腺来源细胞（T细胞），以替代特异性免疫T细胞来传递对绵羊红细胞的二次应答。
Thymus-derived cell (T cell) activation by heterologous antigens as a replacement of specific immune T cells in the transfer of the secondary response to sheep erythrocytes.
作者信息
Mond J J, Takahashi T, Thorbecke G J
出版信息
J Exp Med. 1972 Oct 1;136(4):715-21. doi: 10.1084/jem.136.4.715.
Abstract
Spleen cells from LAF(1) mice hyperimmune to sheep erythrocytes (SE) lost their ability to transfer a secondary response to irradiated recipients after incubation with anti-theta and rabbit complement in vitro. Small numbers of specific immune cells even when taken 3 days after a primary SE injection reconstituted the direct and indirect plaque-forming cell responses. Larger numbers of cells sensitized to B. abortus (or keyhole limpet hemocyanin), and given together with the corresponding antigen, also partially reconstituted the ability to respond to SE. This property was mediated by theta-bearing cells and was interpreted as due to a nonspecific humoral factor liberated by specifically activated T cells and acting on B cell proliferation or maturation.
摘要
来自对绵羊红细胞（SE）高度免疫的LAF(1)小鼠的脾细胞，在体外与抗θ血清和兔补体孵育后，失去了向受辐照受体传递二次反应的能力。即使在初次注射SE后3天获取的少量特异性免疫细胞，也能重建直接和间接的空斑形成细胞反应。大量对流产布鲁氏菌（或钥孔血蓝蛋白）致敏并与相应抗原一起给予的细胞，也能部分重建对SE的反应能力。这种特性由携带θ的细胞介导，被解释为是由于特异性活化的T细胞释放的一种非特异性体液因子作用于B细胞增殖或成熟所致。
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Thymus-derived cell (T cell) activation by heterologous antigens as a replacement of specific immune T cells in the transfer of the secondary response to sheep erythrocytes.通过异源抗原激活胸腺来源细胞（T细胞），以替代特异性免疫T细胞来传递对绵羊红细胞的二次应答。
J Exp Med. 1972 Oct 1;136(4):715-21. doi: 10.1084/jem.136.4.715.
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Effect of recent antigen priming on adoptive immune responses. I. Specific unresponsiveness of cells from lymphoid organs of mice primed with heterologous erythrocytes.近期抗原致敏对过继免疫反应的影响。I. 用异种红细胞致敏的小鼠淋巴器官细胞的特异性无反应性。
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引用本文的文献
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Antibody formation: stimulation by polyadenylic and polycytidylic acids.抗体形成：聚腺苷酸和聚胞苷酸的刺激作用
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Surface antigens of immunocompetent cells. I. Effect of theta and PC.1 alloantisera on the ability of spleen cells to transfer immune responses.免疫活性细胞的表面抗原。I. θ和PC.1同种异体抗血清对脾细胞传递免疫反应能力的影响。
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Reconstitution of a thymus cell-deprived immune system by syngeneic and allogeneic thymocytes in vitro.通过同基因和异基因胸腺细胞在体外重建胸腺细胞缺失的免疫系统。
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