Schindler L, Streissle G, Kirchner H
Infect Immun. 1981 Jun;32(3):1128-31. doi: 10.1128/iai.32.3.1128-1131.1981.
C57BL/6 mice that are highly susceptible to infection with mouse hepatitis virus type 3 were protected against intraperitoneal viral infection by simultaneous intraperitoneal injection of Corynebacterium parvum. No protection was observed when C. parvum was given intravenously or when it was injected intraperitoneally 3 days before viral infection. Protective effects were, however, consistently found when C. parvum was given 2 h before or 2 h after viral infection. Activity was seen only against 10 50% lethal doses and not against 100 50% lethal doses. C. parvum also caused a significant decrease of virus type 3. These data suggest a direct effect of C. parvum on virus-susceptible cells. Injection of C. parvum in mice caused activation of natural killer (NK) cells and of interferon production. However, these two effects were equally demonstrable at high and low doses of C. parvum, whereas protection against mouse hepatitis virus type 3 was not demonstrable at low doses of C. parvum. Thus, antiviral protection may be dissociated from activation of NK cells and induction of interferon.
对3型小鼠肝炎病毒感染高度敏感的C57BL/6小鼠，通过同时腹腔注射微小棒状杆菌，可免受腹腔内病毒感染。当静脉注射微小棒状杆菌或在病毒感染前3天腹腔注射时，未观察到保护作用。然而，当在病毒感染前2小时或感染后2小时给予微小棒状杆菌时，始终能发现保护作用。活性仅针对10个50%致死剂量，而对100个50%致死剂量无效。微小棒状杆菌还导致3型病毒显著减少。这些数据表明微小棒状杆菌对病毒易感细胞有直接作用。在小鼠中注射微小棒状杆菌会导致自然杀伤（NK）细胞活化和干扰素产生。然而，在高剂量和低剂量的微小棒状杆菌下，这两种作用同样明显，而在低剂量的微小棒状杆菌下，对3型小鼠肝炎病毒的保护作用并不明显。因此，抗病毒保护可能与NK细胞活化和干扰素诱导无关。
