豚鼠巨噬细胞抗原诱导的电泳迁移率降低的机制。
The mechanism of antigen-induced electrophoretic mobility reduction of guinea-pig macrophages.
作者信息
Caspary E A
出版信息
Clin Exp Immunol. 1972 Jun;11(2):305-9.
Abstract
The interaction of antigen with sensitized lymphocytes produces a protein substance capable of reducing the electrophoretic mobility of guinea-pig peritoneal macrophages. Reaction with the protein slowing factor also involves some vital synthetic activities of the macrophage. A critical number of lymphocytes is required to initiate the complete reaction suggesting that above this threshold recruitment may take place. It is suggested that the mechanism of action is a close parallel to that of macrophage migration inhibition.
摘要
抗原与致敏淋巴细胞相互作用产生一种能降低豚鼠腹腔巨噬细胞电泳迁移率的蛋白质物质。与蛋白质减慢因子的反应也涉及巨噬细胞的一些重要合成活动。启动完整反应需要一定数量的淋巴细胞，这表明超过此阈值可能会发生募集。有人认为其作用机制与巨噬细胞迁移抑制机制极为相似。
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