Goetz I E, Moklebust R, Warren C J
In Vitro. 1979 Feb;15(2):114-9. doi: 10.1007/BF02618107.
During serial subcultures 50 micrograms per ml gentamicin and penicillin (100 U per ml)-streptomycin (100 micrograms per ml) depressed cell growth signficantly 2 weeks after the addition of the antibiotics; gentamicin, but not penicillin-streptomycin, stimulated cell growth before it became inhibitory. Removal of the antibiotics resulted in the cell yield returning to normal. The results show that these antibiotics can be harmful to cells even at concentrations thought to be safe.
在连续传代培养过程中，每毫升50微克庆大霉素以及青霉素（每毫升100单位）-链霉素（每毫升100微克）在添加抗生素两周后显著抑制细胞生长；庆大霉素在产生抑制作用之前刺激了细胞生长，而青霉素-链霉素则没有。去除抗生素后细胞产量恢复正常。结果表明，即使在被认为是安全的浓度下，这些抗生素也可能对细胞有害。
