抗巨噬细胞、抗胸腺细胞、抗淋巴细胞和抗脾血清对小鼠免疫反应的影响。
Effects of antimacrophage, antithymocyte, antilymphocyte and antispleen serum on the immune response in mice.
作者信息
Argyris B F, Plotkin D H
出版信息
Clin Exp Immunol. 1970 Oct;7(4):551-64.
The effect of antimacrophage serum (AMS) on antibody production was compared to that of antithymocyte (ATS) and antilymphocyte (ALS) serum. All three types of antisera inhibited antibody production to SRBC in mice. Antispleen serum was not immunosuppressive. Immunosuppression could best be demonstrated when the antisera were injected 3 days before a low dose of antigen (10 or 5 × 10 SRBC). None of the antisera affected secondary antibody production. There was no correlation between the immunosuppressive potency of the antisera and their cytotoxic or lymphopenic acitivity. AMS inhibited phagocytosis, whereas ATS and ALS enhanced phagocytosis. So far we have been unable to absorb out immunosuppressive activity of the antisera but have been able to absorb out cytotoxic activity. The significance of these findings is discussed.
将抗巨噬细胞血清（AMS）对抗体产生的影响与抗胸腺细胞血清（ATS）和抗淋巴细胞血清（ALS）的影响进行了比较。所有这三种抗血清均抑制小鼠对绵羊红细胞（SRBC）的抗体产生。抗脾血清没有免疫抑制作用。当在低剂量抗原（10或5×10个SRBC）注射前3天注射抗血清时，免疫抑制作用最明显。没有一种抗血清影响二次抗体产生。抗血清的免疫抑制效力与其细胞毒性或淋巴细胞减少活性之间没有相关性。AMS抑制吞噬作用，而ATS和ALS增强吞噬作用。到目前为止，我们还无法去除抗血清的免疫抑制活性，但能够去除细胞毒性活性。对这些发现的意义进行了讨论。
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