胸腺体液因子活性的淋巴样靶细胞特性研究。
Studies on characterization of the lymphoid target cell for activity of a thymus humoral factor.
作者信息
Rotter V, Globerson A, Nakamura I, Trainin N
出版信息
J Exp Med. 1973 Jul 1;138(1):130-42. doi: 10.1084/jem.138.1.130.
Abstract
The immune response to SRBC was measured in the spleens of adult thymectomized, total body irradiated mice injected with various combinations of thymus and bone marrow cells together with thymic humoral factor (THF). It was found that the number of plaque-forming cells was significantly increased when THF was given in vivo immediately after thymus cell administration or when thymus cells were incubated in THF before injection. On the other hand, bone marrow cells equally treated did not manifest any T cell activity, since THF-treated bone marrow cells were not able to substitute thymus cells in the system used. The results accumulated in the present experiments indicate, therefore, that the target cells for THF activity are thymus cells which acquire a higher T helper cell capacity after THF treatment.
摘要
在成年胸腺切除、全身照射的小鼠脾脏中，检测对绵羊红细胞（SRBC）的免疫反应。这些小鼠注射了胸腺细胞、骨髓细胞与胸腺体液因子（THF）的各种组合。结果发现，在给予胸腺细胞后立即在体内给予THF，或者在注射前将胸腺细胞在THF中孵育时，噬斑形成细胞的数量显著增加。另一方面，经过同样处理的骨髓细胞未表现出任何T细胞活性，因为在所用系统中，经THF处理的骨髓细胞无法替代胸腺细胞。因此，本实验积累的结果表明，THF活性的靶细胞是胸腺细胞，其在THF处理后获得更高的T辅助细胞能力。
相似文献
1
Studies on characterization of the lymphoid target cell for activity of a thymus humoral factor.胸腺体液因子活性的淋巴样靶细胞特性研究。
J Exp Med. 1973 Jul 1;138(1):130-42. doi: 10.1084/jem.138.1.130.
2
Cell to cell interaction in the immune response. V. Target cells for tolerance induction.免疫反应中的细胞间相互作用。五、诱导耐受的靶细胞。
J Exp Med. 1970 Apr 1;131(4):675-99. doi: 10.1084/jem.131.4.675.
3
4
Some endocrine aspects of the thymus gland.胸腺的一些内分泌方面
Jpn J Med Sci Biol. 1976 Dec;29(6):289-321. doi: 10.7883/yoken1952.29.289.
5
Effect of recent antigen priming on adoptive immune responses. I. Specific unresponsiveness of cells from lymphoid organs of mice primed with heterologous erythrocytes.近期抗原致敏对过继免疫反应的影响。I. 用异种红细胞致敏的小鼠淋巴器官细胞的特异性无反应性。
J Exp Med. 1973 Jul 1;138(1):143-62. doi: 10.1084/jem.138.1.143.
6
Cell to cell interaction in the immune response. II. The source of hemolysin-forming cells in irradiated mice given bone marrow and thymus or thoracic duct lymphocytes.免疫反应中的细胞间相互作用。II. 给受照射小鼠输注骨髓、胸腺或胸导管淋巴细胞后溶血素形成细胞的来源。
J Exp Med. 1968 Oct 1;128(4):821-37. doi: 10.1084/jem.128.4.821.
7
Immunological memory in mice. II. Cell interactions in the secondary immune response studies by means of immunoglobulin allotype markers.小鼠的免疫记忆。II. 通过免疫球蛋白同种异型标记研究二次免疫应答中的细胞相互作用。
J Exp Med. 1970 Jun 1;131(6):1109-20. doi: 10.1084/jem.131.6.1109.
8
Stimulation of humoral antibody formation by polyanions. 3. Restoration of the immune response to sheep red blood cells by polyanions in thymectomized and lethally irradiated mice protected with bone marrow cells.多聚阴离子对体液抗体形成的刺激作用。3. 多聚阴离子对经胸腺切除和致死性照射并用骨髓细胞保护的小鼠体内针对绵羊红细胞免疫反应的恢复作用。
Eur J Immunol. 1971 Aug;1(4):302-4. doi: 10.1002/eji.1830010418.
9
Studies of the immunological capacity of germ-free mouse radiation chimeras. II. Thymus cell function in a humoral immune response to sheep erythrocytes.无菌小鼠辐射嵌合体免疫能力的研究。II. 对绵羊红细胞体液免疫应答中的胸腺细胞功能。
Cell Immunol. 1973 Oct;9(1):118-26. doi: 10.1016/0008-8749(73)90173-1.
引用本文的文献
1
Increased reactivity of mouse spleen cells sensitized in vitro against syngeneic tumor cells in the presence of a thymic humoral factor.在胸腺体液因子存在的情况下，体外致敏的小鼠脾细胞对同基因肿瘤细胞的反应性增加。
J Exp Med. 1973 Dec 1;138(6):1521-32. doi: 10.1084/jem.138.6.1521.
2
Hormone-like activity of a thymus humoral factor on the induction of immune competence in lymphoid cells.胸腺体液因子对淋巴细胞免疫能力诱导的类激素活性
J Exp Med. 1974 Jan 1;139(1):193-207. doi: 10.1084/jem.139.1.193.
3
THF-gamma 2, a thymic hormone, increases immunocompetence and survival in 5-fluorouracil-treated mice bearing MOPC-315 plasmacytoma.胸腺素γ2，一种胸腺激素，可增强5-氟尿嘧啶处理的携带MOPC-315浆细胞瘤小鼠的免疫能力并提高其存活率。
Cancer Immunol Immunother. 1989;30(2):119-25. doi: 10.1007/BF01665963.
4
Amplification of the proliferative response to alloantigen by a factor present in an extract of syngeneic thymic lymphoid cells.同基因胸腺淋巴细胞提取物中一种因子对同种异体抗原增殖反应的增强作用。
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4474-8. doi: 10.1073/pnas.75.9.4474.
5
Evaluation of functional thymic hormones in Arabian horses with severe combined immunodeficiency.对患有严重联合免疫缺陷的阿拉伯马的功能性胸腺激素的评估。
Clin Exp Immunol. 1979 Oct;38(1):37-44.
6
Enrichment of in vitro and in vivo immunologic activity of purified fractions of calf thymic hormone.小牛胸腺激素纯化组分的体外和体内免疫活性增强。
J Exp Med. 1978 Jul 1;148(1):71-83. doi: 10.1084/jem.148.1.71.
本文引用的文献
1
Reactivation in vitro of immunocompetence in irradiated mouse spleen.照射鼠脾免疫活性的体外再激活。
J Exp Med. 1967 Aug 1;126(2):223-34. doi: 10.1084/jem.126.2.223.
2
Contribution of a thymic humoral factor to the development of an immunologically competent population from cells of mouse bone marrow.胸腺体液因子对从小鼠骨髓细胞发育出免疫活性细胞群体的作用。
J Exp Med. 1971 Sep 1;134(3 Pt 1):786-800. doi: 10.1084/jem.134.3.786.
3
HUMORAL THYMIC FACTOR IN MICE: FURTHER EVIDENCE.小鼠体内的体液胸腺因子：进一步的证据。
Science. 1964 Mar 6;143(3610):1049-51. doi: 10.1126/science.143.3610.1049.
4
EVIDENCE FOR A HUMORAL THYMUS FACTOR RESPONSIBLE FOR THE MATURATION OF IMMUNOLOGICAL FACULTY.一种负责免疫功能成熟的体液胸腺因子的证据。
Nature. 1963 Aug 17;199:653-4. doi: 10.1038/199653a0.
5
EVIDENCE FOR FUNCTION OF THYMIC TISSUE IN DIFFUSION CHAMBERS IMPLANTED IN NEONATALLY THYMECTOMIZED MICE. PRELIMINARY REPORT.植入新生期切除胸腺小鼠扩散盒中的胸腺组织功能的证据。初步报告。
J Natl Cancer Inst. 1963 Aug;31:199-217.
6
Increase in antibody-forming cells ofneonatally thymectomized mice receiving calf thymus extract.接受小牛胸腺提取物的新生期切除胸腺小鼠的抗体形成细胞增加。
Nature. 1967 Oct 28;216(5113):377-9. doi: 10.1038/216377a0.
7
A thymic factor preventing wasting and influencing lymphopoiesis in mice.一种预防小鼠消瘦并影响淋巴细胞生成的胸腺因子。
Isr J Med Sci. 1966 Sep-Oct;2(5):549-59.
8
Restoration of immunologic reactivity of thymectomized mice by calf thymus extracts.
Cancer Res. 1967 Feb;27(2):309-13.
9
The effects of thymus and other lymphoid organs enclosed in millipore diffusion chambers on neonatally thymectomized mice.置于微孔扩散小室中的胸腺及其他淋巴器官对新生期切除胸腺小鼠的影响。
J Exp Med. 1965 Sep 1;122(3):633-50. doi: 10.1084/jem.122.3.633.
10
Immunologic complementation between thymus and marrow cells--a model for the two-cell theory of immunocompetence.胸腺细胞与骨髓细胞之间的免疫互补——免疫活性双细胞理论的一个模型。
Transplant Rev. 1969;1:92-113. doi: 10.1111/j.1600-065x.1969.tb00137.x.
Zotero 插件