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Studies on the conversion of proinsulin to insulin. 3. Studies in vitro with a crude secretion granule fraction isolated from rat islets of Langerhans.

作者信息

Kemmler W, Steiner D F, Borg J

出版信息

J Biol Chem. 1973 Jul 10;248(13):4544-51.

PMID:4578085
Abstract
摘要

相似文献

1
Studies on the conversion of proinsulin to insulin. 3. Studies in vitro with a crude secretion granule fraction isolated from rat islets of Langerhans.胰岛素原向胰岛素转化的研究。3. 用从大鼠胰岛分离的粗分泌颗粒组分进行的体外研究。
J Biol Chem. 1973 Jul 10;248(13):4544-51.
2
Studies on the conversion of proinsulin to insulin in the isolated islets of Langerhans in the rat.大鼠胰岛中胰岛素原向胰岛素转化的研究。
Can J Physiol Pharmacol. 1973 Mar;51(3):175-82. doi: 10.1139/y73-025.
3
The effect of tolbutamide and glibenclamide on the incorporation of ( 3 H)leucine and on the conversion of proinsulin to insulin in isolated pancreatic islets.甲苯磺丁脲和格列本脲对分离的胰岛中（3H）亮氨酸掺入及胰岛素原向胰岛素转化的影响。
FEBS Lett. 1972 Oct 1;26(1):237-40. doi: 10.1016/0014-5793(72)80581-7.
4
Subcellular localization of proinsulin to insulin conversion in isolated rat islets.原胰岛素在分离的大鼠胰岛中向胰岛素转化的亚细胞定位。
Endocrinology. 1970 Jan;86(1):88-96. doi: 10.1210/endo-86-1-88.
5
Stimulation by ATP of proinsulin to insulin conversion in isolated rat pancreatic islet secretory granules. Association with the ATP-dependent proton pump.三磷酸腺苷（ATP）对分离的大鼠胰岛分泌颗粒中胰岛素原向胰岛素转化的刺激作用。与ATP依赖性质子泵的关联。
J Biol Chem. 1987 Aug 5;262(22):10712-7.
6
The conversion of proinsulin into insulin in the -cells of mammals and fishes.哺乳动物和鱼类β细胞中胰岛素原向胰岛素的转化。
Biochem J. 1971 Dec;125(3):49P-50P. doi: 10.1042/bj1250049p.
7
Fractionation of islet tissue in processing proinsulin to insulin.
Methods Enzymol. 1974;31:374-8. doi: 10.1016/0076-6879(74)31041-5.
8
Conversion of proinsulin to insulin: involvement of a 31,500 molecular weight thiol protease.胰岛素原向胰岛素的转化：一种分子量为31,500的巯基蛋白酶的参与。
Proc Natl Acad Sci U S A. 1982 Aug;79(15):4613-7. doi: 10.1073/pnas.79.15.4613.
9
Inhibition of proinsulin to insulin conversion in rat islets using arginine and lysine analogs. Lack of effect on rate of release of modified products.使用精氨酸和赖氨酸类似物抑制大鼠胰岛中胰岛素原向胰岛素的转化。对修饰产物释放速率无影响。
J Biol Chem. 1982 Nov 25;257(22):13177-80.
10
Role of ATP in the intracellular translocation of proinsulin and insulin in the rat pancreatic B cell.
Nat New Biol. 1972 Jan 19;235(55):85-6. doi: 10.1038/newbio235085a0.

引用本文的文献

1
Adventures with insulin in the islets of Langerhans.在胰岛中探索胰岛素。
J Biol Chem. 2011 May 20;286(20):17399-421. doi: 10.1074/jbc.X111.244764. Epub 2011 Mar 28.
2
Sorting and processing of secretory proteins.分泌蛋白的分选与加工
Biochem J. 1994 Apr 1;299 ( Pt 1)(Pt 1):1-18. doi: 10.1042/bj2990001.
3
Viral glycoproteins as determinants of pathogenicity.病毒糖蛋白作为致病性的决定因素。
Med Microbiol Immunol. 1982;170(3):145-53. doi: 10.1007/BF02298195.
4
Heterogeneity and compartmental properties of insulin storage and secretion in rat islets.大鼠胰岛中胰岛素储存与分泌的异质性和区室特性。
J Clin Invest. 1982 Mar;69(3):554-63. doi: 10.1172/jci110481.
5
Isolation and characterization of tryase, a serine proteinase from rat liver.大鼠肝脏丝氨酸蛋白酶胰蛋白酶的分离与鉴定
Biochem J. 1981 Jan 1;193(1):251-9. doi: 10.1042/bj1930251.
6
Characterization of proinsulin- and proglucagon-converting activities in isolated islet secretory granules.分离胰岛分泌颗粒中胰岛素原和胰高血糖素原转化活性的表征
J Cell Biol. 1981 Aug;90(2):312-22. doi: 10.1083/jcb.90.2.312.
7
Angiotensin II immunoreactivity coexists with renin in the juxtaglomerular granular cells of the kidney.血管紧张素II免疫反应性与肾素共存于肾脏的球旁颗粒细胞中。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3897-900. doi: 10.1073/pnas.78.6.3897.
8
In vitro conversion of proinsulin to insulin by cathepsin B in isolated islets and its inhibition by cathepsin B antibodies.
Acta Diabetol Lat. 1980 Jul-Dec;17(3-4):255-66. doi: 10.1007/BF02581326.
9
Conversion of proinsulin to insulin: involvement of a 31,500 molecular weight thiol protease.胰岛素原向胰岛素的转化：一种分子量为31,500的巯基蛋白酶的参与。
Proc Natl Acad Sci U S A. 1982 Aug;79(15):4613-7. doi: 10.1073/pnas.79.15.4613.
10
Insulin, not C-peptide (proinsulin), is present in crinophagic bodies of the pancreatic B-cell.胰岛素而非C肽（胰岛素原）存在于胰腺B细胞的噬分泌粒小体中。
J Cell Biol. 1984 Jan;98(1):222-8. doi: 10.1083/jcb.98.1.222.