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1
Chronic liver disease and mitochondrial antibodies: a family study.慢性肝病与线粒体抗体：一项家族研究。
Br Med J. 1972 Jan 15;1(5793):146-8. doi: 10.1136/bmj.1.5793.146.
2
Familial occurrence of primary biliary cirrhosis associated with hypergammaglobulinemia in descendants: a family study.原发性胆汁性肝硬化伴高球蛋白血症在后代中的家族性发病：一项家族研究。
Gastroenterology. 1980 Mar;78(3):549-55.
3
Familial primary biliary cirrhosis. Immunological and genetic study.
Am J Gastroenterol. 1981 Mar;75(3):188-91.
4
High prevalence of seroimmunologic abnormalities in relatives of patients with active chronic hepatitis or primary biliary cirrhosis.活动性慢性肝炎或原发性胆汁性肝硬化患者亲属中血清免疫异常的高患病率。
N Engl J Med. 1974 Jan 10;290(2):63-9. doi: 10.1056/NEJM197401102900201.
5
[Enigma harbors in PBC].原发性胆汁性胆管炎中存在的谜团
Nihon Shokakibyo Gakkai Zasshi. 2006 Apr;103(4):385-90.
6
Immunogenetical penetrance in patients with primary biliary cirrhosis.原发性胆汁性肝硬化患者的免疫遗传学外显率。
Jpn J Med. 1990 Sep-Oct;29(5):533-6. doi: 10.2169/internalmedicine1962.29.533.
7
Editorial: Genetic "markers" of chronic liver disease?社论：慢性肝病的基因“标志物”？
N Engl J Med. 1974 Jan 10;290(2):103-4. doi: 10.1056/NEJM197401102900210.
8
[Autoantibodies, immunoglobulins and HLA in relatives of patients with primary biliary cirrhosis].[原发性胆汁性肝硬化患者亲属中的自身抗体、免疫球蛋白及人类白细胞抗原]
Rev Esp Enferm Apar Dig. 1983 Nov;64(5):395-9.
9
Primary biliary cirrhosis and chronic active hepatitis in two sisters.两姐妹患原发性胆汁性肝硬化和慢性活动性肝炎。
Br Med J. 1976 Sep 4;2(6035):566. doi: 10.1136/bmj.2.6035.566.
10
Antimitochondrial antibodies in primary biliary cirrhosis.
J Hepatol. 1986;2(1):123-31. doi: 10.1016/s0168-8278(86)80015-0.

引用本文的文献

1
Prevalence and pattern of familial disease in primary biliary cirrhosis.原发性胆汁性肝硬化中家族性疾病的患病率及模式
Gut. 1995 Apr;36(4):615-7. doi: 10.1136/gut.36.4.615.
2
Serology of primary biliary cirrhosis.原发性胆汁性肝硬化的血清学
Springer Semin Immunopathol. 1980 Dec;3(3):355-73. doi: 10.1007/BF02054110.
3
Mitochondrial antibodies (AMA).线粒体抗体（AMA）。
Gut. 1974 Aug;15(8):664-8. doi: 10.1136/gut.15.8.664.
4
Studies on drug-induced lupus erythematosus in mice. II. Drug-induced smooth muscle and skeletal muscle antibodies.小鼠药物性红斑狼疮的研究。II. 药物诱导的平滑肌和骨骼肌抗体。
Clin Exp Immunol. 1973 Nov;15(3):375-84.
5
Evaluation of a tanned red cell technique for thyroid microsomal antibodies.用于检测甲状腺微粒体抗体的鞣酸红细胞技术的评估
J Clin Pathol. 1973 Aug;26(8):623-7. doi: 10.1136/jcp.26.8.623.
6
ABO blood groups, Rhesus negativity, and primary biliary cirrhosis.ABO血型、恒河猴阴性与原发性胆汁性肝硬化。
Gut. 1974 Jun;15(6):480-1. doi: 10.1136/gut.15.6.480.
7
Familial primary biliary cirrhosis associated with impaired concanavalin A-induced lymphocyte transformation in relatives. Two family studies.家族性原发性胆汁性肝硬化与亲属中伴刀豆球蛋白A诱导的淋巴细胞转化受损。两项家族研究。
Dig Dis Sci. 1992 Mar;37(3):353-60. doi: 10.1007/BF01307727.
8
Primary biliary cirrhosis in brothers.兄弟患原发性胆汁性肝硬化
Postgrad Med J. 1975 Feb;51(592):110-5. doi: 10.1136/pgmj.51.592.110.
9
Are increased individual susceptibility and environmental factors both necessary for the development of primary biliary cirrhosis?原发性胆汁性肝硬化的发生是否既需要个体易感性增加又需要环境因素？
Br Med J. 1979 Aug 18;2(6187):419-20. doi: 10.1136/bmj.2.6187.419.

本文引用的文献

1
HEREDITARY HYPERGAMMAGLOBULINEMIA AND LUPOID HEPATITIS.
Acta Med Scand. 1965 Jun;177:751-9. doi: 10.1111/j.0954-6820.1965.tb01885.x.
2
FAMILIAL CIRRHOSIS: A CLINICAL AND PATHOLOGICAL STUDY.家族性肝硬化：一项临床与病理研究。
Ann Intern Med. 1964 Oct;61:667-79. doi: 10.7326/0003-4819-61-4-667.
3
ANTINUCLEAR ANTIBODIES IN FAMILIES OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS.系统性红斑狼疮患者家族中的抗核抗体
N Engl J Med. 1964 Jul 23;271:165-71. doi: 10.1056/NEJM196407232710401.
4
Tissue antibodies in primary biliary cirrhosis, active chronic (lupoid) hepatitis, cryptogenic cirrhosis and other liver diseases and their clinical implications.原发性胆汁性肝硬化、活动性慢性（类狼疮样）肝炎、隐源性肝硬化及其他肝脏疾病中的组织抗体及其临床意义。
Clin Exp Immunol. 1966 Jul;1(3):237-62.
5
Mitochondrial and other tissue autoantibodies in patients with biological false positive reactions for syphilis.梅毒生物学假阳性反应患者的线粒体及其他组织自身抗体
Clin Exp Immunol. 1970 Jun;6(6):871-84.
6
Serum hepatitis antigen (SH): rapid detection by high voltage immunoelectroosmophoresis.血清肝炎抗原（SH）：通过高压免疫电渗电泳进行快速检测。
Science. 1970 Aug 7;169(3945):593-5. doi: 10.1126/science.169.3945.593.
7
Mitochondrial antibodies and subclinical liver disease.线粒体抗体与亚临床肝病
Q J Med. 1970 Jan;39(153):31-48.
8
A genetic approach to the pathogenesis of hepatic cirrhosis. A clinical and serological study.肝硬化发病机制的遗传学研究方法。一项临床和血清学研究。
Acta Med Scand. 1966 May;179(5):527-33. doi: 10.1111/j.0954-6820.1966.tb07969.x.
9
Australia antigen in familial cirrhosis.家族性肝硬化中的澳大利亚抗原
Lancet. 1971 Jan 30;1(7692):244. doi: 10.1016/s0140-6736(71)90989-5.
10
Familial cirrhosis with autoimmune features and raised immunoglobulin levels.具有自身免疫特征和免疫球蛋白水平升高的家族性肝硬化
Gastroenterology. 1970 Oct;59(4):546-52.

慢性肝病与线粒体抗体：一项家族研究。

Chronic liver disease and mitochondrial antibodies: a family study.

作者信息

Walker J G, Bates D, Doniach D, Ball P A, Sherlock S

出版信息

Br Med J. 1972 Jan 15;1(5793):146-8. doi: 10.1136/bmj.1.5793.146.

DOI:10.1136/bmj.1.5793.146
PMID:5007841
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1787106/
Abstract

Two sisters had primary biliary disease and associated autoimmune thyroiditis with high titres of mitochondrial and other autoantibodies. Their deceased mother possibly suffered from similar disorders. In the same family two brothers had multiple autoimmune reactions, including mitochondrial antibodies, but liver function tests gave normal results. Ten other close relatives were investigated. Australia antigen was not found in the proband or her relatives.

摘要

两姐妹患有原发性胆汁性疾病及相关的自身免疫性甲状腺炎，伴有高滴度的线粒体抗体和其他自身抗体。她们已故的母亲可能也患有类似疾病。在同一家庭中，两兄弟有多种自身免疫反应，包括线粒体抗体，但肝功能检查结果正常。另外对十名近亲进行了调查。先证者及其亲属均未发现澳大利亚抗原。